Eudaxen 50 mg (Tablet)

Indications

• Treatment of intractable hypoglycemia
• Management of severe hypoglycemia symptoms
• Effective for idiopathic hypoglycemia in infancy
• Suitable for leucine-sensitive hypoglycemia
• Useful for glycogen storage disease
• Indicated for hypoglycemia of unknown origin

Description

Eudaxen is a benzothiadiazine used orally in the management of intractable hypoglycemia and intravenously in hypertensive emergencies. It is a peripheral vasodilator that increases plasma glucose concentration, inhibits insulin secretion, and has various pharmacological properties such as antihypertensive, sodium channel blocking, vasodilating, and diuretic effects.

Pharmacology

• Acts as a diuretic
• Inhibits insulin release from the pancreas
• Enhances cell membrane permeability to potassium ions
• Relaxes local smooth muscles by switching off voltage-gated calcium ion channels

Dosage & Administration

• Starting oral dose of 5mg/kg body weight
• Regular blood glucose level determinations
• Usual maintenance dose of 3-8mg/kg/day
• Reduced doses may be required for renal impairment
• Higher dosages for specific conditions

Interaction

• Potentiates oral diuretics, antihypertensive agents, and anticoagulants
• Alters phenytoin levels
• Increased risk of hyperglycemia with corticosteroids or estrogen-progestogen combinations

Contraindications

• Not suitable for cases amenable to surgery or specific therapy
• Hypersensitivity to any component
• Contraindicated in cases of thiazide hypersensitivity

Side Effects

• Thrombocytopenia
• Pancreatitis
• Hypotension
• Diarrhea
• Heart failure
• Other potential adverse reactions

Pregnancy & Lactation

• Revealed fetal resorptions and delays in parturition in animal studies
• Demonstrated to cross the placental barrier and cause degeneration of fetal pancreatic beta cells
• Potential teratogenic effects
• Limited use in pregnant women for specified conditions
• Consideration of potential benefits vs. harmful effects
• Possible alopecia in newborns from prolonged therapy
• No adequate data on excretion in breast milk

Precautions & Warnings

• Regular monitoring of blood pressure
• Likely need for therapy with oral diuretics in sodium and water retention
• Potential need for urinary volume maintenance in severe renal failure
• Caution in patients with cardiac failure or impaired cardiac reserve
• Cautious use in patients with cardiovascular disorders
• Monitoring of serum uric acid concentration
• Regular haematological examinations and growth assessments in children
• Careful dosage for patients with lower plasma proteins

Overdose Effects

• Hyperglycemia
• Management with insulin in severe cases
• Requirement of intravenous fluids and sympathomimetics for hypotension

Therapeutic Class

• Combination oral hypoglycemic preparations

Storage Conditions

• Store below 30°C
• Original container for moisture protection
• Keep out of reach and sight of children

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