Niranib 100 mg (Capsule)
Unit Price: ৳ 833.33 (1 x 30: ৳ 25,000.00)
Strip Price: ৳ 25,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Niraparib |
| Company | Everest pharmaceuticals ltd |
Indications
- Maintenance treatment
- Epithelial ovarian cancer
- Fallopian tube cancer
- Primary peritoneal cancer
- Platinum-based chemotherapy
Pharmacology
- PARP inhibitor
- DNA repair
- Cytotoxicity
- Apoptosis induction
- DNA damage
- BRCA1/2 deficiency
- Tumor growth inhibition
- Metabolism by carboxylesterases
Dosage & Administration
- Recommended dose 300 mg
- Oral administration
- Once daily
- Swallow whole
- Can be taken with or without food
- Bedtime administration
- Start treatment within 8 weeks after platinum-containing regimen
Interaction
- Inhibition of CYPs
- CYP3A4 caution
- Induction of CYPs
- CYP1A2 caution
Contraindications
- Hypersensitivity to active substance
- Hypersensitivity to excipients
- Breastfeeding
Side Effects
- Nausea
- Thrombocytopenia
- Fatigue
- Anaemia
- Constipation
- Vomiting
- Abdominal pain
- Neutropenia
- Insomnia
- Headache
- Decreased appetite
- Diarrhea
- Dyspnea
- Hypertension
- Dyspepsia
- Back pain
- Dizziness
- Cough
- Urinary tract infection
- Arthralgia
- Palpitations
- Dysgeusia
Pregnancy & Lactation
- Pregnancy test required
- Contraception during therapy
- Embryonic or fetal harm potential
- Breastfeeding contraindicated
- Fertility impact in animal studies
Precautions & Warnings
- Myelodysplastic syndrome/acute myeloid leukaemia risk
- Hypertension risk
- Pregnancy precautions
- Lactose intolerance caution
- Tartrazine allergy warning
Use in Special Populations
- Elderly use
- Pediatric use
- Renal impairment caution
- Hepatic impairment caution
Overdose Effects
- No specific treatment
- General supportive measures
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Cool and dry storage
- Do not exceed 30°C
- Avoid exposure to high temperatures
- Keep out of reach of children