Osmifen 60 mg (Tablet)
Unit Price: ৳ 30.00 (3 x 10: ৳ 900.00)
Strip Price: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ospemifene |
| Company | Nuvista pharma ltd |
Indications
- Treatment of dyspareunia
- Treatment of vulvar and vaginal atrophy
- Menopause symptom relief
Pharmacology
- Next-generation SERM
- Estrogen receptor modulator
- Agonistic effect on the endometrium
- Tissue selective effects
Dosage & Administration
- 60 mg tablet
- Once daily with food
- Treatment of moderate to severe dyspareunia
- Treatment of vaginal dryness
Interaction
- Metabolized by CYP3A4 and CYP2C9
- Avoid concomitant use with estrogens
- Avoid concomitant use with fluconazole
- Avoid concomitant use with rifampin
- Avoid concomitant use with ketoconazole
- Effect on highly protein-bound drugs
- Risk of adverse reactions with multiple enzyme inhibition
Contraindications
- Undiagnosed abnormal genital bleeding
- Estrogen-dependent neoplasia
- Active DVT or PE
- Active arterial thromboembolic disease
- Hypersensitivity to any ingredients
- Pregnancy or potential pregnancy
Side Effects
- Cardiovascular disorders
- Malignant neoplasms
- Hot flush
- Vaginal discharge
- Muscle spasms
- Hyperhidrosis
Pregnancy & Lactation
- Contraindicated in pregnancy
- Likely risk of adverse outcomes
- Excretion in breast milk
- Not recommended during lactation
Precautions & Warnings
- Risk factors for cardiovascular disorders
- Management of venous thromboembolism
- Endometrial and breast cancer monitoring
- Stroke incidence rates
- Coronary heart disease risks
- VTE management and discontinuation
- Severe hepatic impairment contraindication
- Hypersensitivity reactions
- Importance of reporting vaginal bleeding
- Potential hot flashes occurrence
- Carcinogenesis and mutagenesis findings
- Impairment of fertility observations
Use in Special Populations
- Not indicated in children
- No pediatric clinical studies conducted
- Geriatric population safety
- Renal impairment pharmacokinetics
- No hepatic impairment study conducted
Therapeutic Class
- Drugs used in vaginal and vulval conditions
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of the reach of children