Colaz 400 mg (Chewable Tablet)
Unit Price: ৳ 5.00 (30's pack: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Albendazole |
| Company | Cosmic pharma ltd |
| Also available as |
Indications
- Hookworm (Ancylostoma, Necator)
- Roundworm (Ascaris)
- Threadworm (Enterobius)
- Whipworm (Trichuris)
- Strongyloides
- Tapeworm
- Opisthorchi
- Hydatid
Description
Benzimidazole anthelmintic with vermicidal, ovicidal, and larvicidal activity
Pharmacology
- Broad spectrum anthelmintic
- Blocks glucose uptake in susceptible helminths
- Exerts anthelmintic effect by immobilizing parasite
- Extensively metabolized, probably in the liver
- Poorly absorbed from the gastrointestinal tract
- Metabolite albendazole sulphoxide has anthelmintic activity and a plasma half-life of about 8.5 hrs
- Excreted in the urine together with other metabolites
Dosage & Administration
- Adults & children over 2 years:
- 400 mg (1 tablet or 10 ml suspension) as a single dose in cases of Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale and Necator americanus
- In cases of strongyloidiasis or taeniasis, 400 mg (1 tablet or 10 ml suspension) daily should be given for 3 consecutive days. If the patient is not cured on follow-up after three weeks, a second course of treatment is indicated.
- Children of 1-2 years: Recommended dose is a single dose of 200 mg (5 ml suspension)
- Children under 1 year: Not recommended
- Hydatid disease (Echinococcosis):
- 400 mg twice daily for 28 days for patients weighing over 60 kg
- 15 mg/kg body weight daily in two divided doses (to a maximum total daily dose of 800 mg) for patients weighing less than 60 kg
- For cystic echinococcosis, the 28 days course may be repeated after 14 days without treatment, to a total of 3 treatment cycles
- For alveolar echinococcosis, cycles of 28 days of treatment followed by 14 days without treatment, may need to continue for months or years
- In giardiasis, 400 mg (1 tablet or 10 ml suspension) once daily for five days
Interaction
No interaction reported
Contraindications
- Not normally used in neonates
- Reduction of the dose from 400 mg to 200 mg may be indicated in children weighing less than 10 kg but there are no grounds for a general reduction in dosage to children
- Should not be given during pregnancy or women thought to be pregnant
- No evidence to suggest that dose should be altered in renal, hepatic or cardiac failure
Side Effects
- Gastrointestinal disturbances
- Headache
- Dizziness
- Changes in liver enzymes
- Reversible alopecia
- Rash
- Fever
- Blood disorders including leucopenia and pancytopenia
- Allergic shock if cyst leakage
- Convulsion and meningism in cerebral disease
Pregnancy & Lactation
Albendazole should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus
Precautions & Warnings
- Blood counts and liver function tests before treatment and twice during each cycle
- Breastfeeding
- Exclude pregnancy before starting treatment
- Use in the treatment of Echinococcosis only under constant medical supervision with regular monitoring of serum-transaminase concentrations and of leucocyte and platelet counts
Therapeutic Class
Anthelmintic
Storage Conditions
Keep in a dry place, away from light and heat. Keep out of the reach of children