Thiontal 1 gm/vial (IV Injection)
1 gm vial: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Thiopental sodium |
| Company | Renata limited |
| Also available as |
Indications
- Sole anesthetic agent for brief procedures
- Induction of anesthesia prior to other agents
- Regional anesthesia supplementation
- Hypnosis during balanced anesthesia
- Control of convulsive states
- Neurosurgical patients with increased intracranial pressure
- Narcoanalysis and narcosynthesis in psychiatric disorders
Composition
- Thiopental 500 mg injection
- Thiopental 1 gm injection
Pharmacology
- Ultrashort-acting depressant of the central nervous system
- Binds at GABAA receptor
- Produces hypnosis within 30 to 40 seconds
- Rapid recovery after small dose
- Prolonged anesthesia with repeated doses
Dosage & Administration
- Administered intravenously as 2.5% w/v solution
- Premedication with atropine or scopolamine
- Test dose for tolerance assessment
- Normal dosage for induction of anesthesia
- Dosage considerations for adults, children, and elderly
- Use in convulsive states
Interaction
- Possible increase in difficulty in producing anesthesia with alcohol or CNS depressants
- Additive action with other CNS depressants
- Hypotension and excitatory effects with phenothiazine antipsychotics
- Decreased requirement of Thiontal with certain drugs
Contraindications
- Absence of suitable veins for intravenous administration
- Hypersensitivity to barbiturates
- Porphyria
- Status asthmaticus
- Severe cardiovascular disease
- Hypotension or shock
- Conditions prolonging or potentiating hypnotic effect
Side Effects
- Hypersensitivity reactions
- Respiratory and myocardial depression
- Cardiac arrhythmias
- Hypotension and tachycardia
- Sneezing, coughing, bronchospasm
- Anaphylactic reactions
Pregnancy & Lactation
- Pregnancy Category C
- Crosses the placental barrier
- May appear in milk of nursing mothers
Precautions & Warnings
- Constant anesthesia management attendance
- Caution with preexisting hypotension
- Potential habit-forming nature
- Availability of resuscitative equipment and oxygen
- Anesthesia administration by qualified persons
- Avoid extravasations or intra-arterial injection
Overdose Effects
- Too rapid or repeated administration may lead to overdose
- Alarming fall in blood pressure
- Respiratory difficulties and laryngospasm
- Discontinue in case of suspected overdosage
Therapeutic Class
- General (Intravenous) anesthetics
Storage Conditions
- Store at controlled room temperature of 15°C to 30°C
- Solutions should be freshly prepared and used immediately
- Discard any remaining portion of the contents