Amibac 100 mg/2 ml (IM/IV Injection)

2 ml ampoule: ৳ 16.06 (2 x 5: ৳ 160.60)

Medicine Details

Category Details
Generic Amikacin
Company Popular pharmaceuticals ltd
Also available as
Amibac 500 mg injection

Title

  • Amikacin Sulfate Injection

Categories

  • Medicine
  • Pharmaceuticals
  • Antibiotics

Description

  • Indications:
    • Short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria
    • Effective in bacterial septicemia, serious respiratory tract infections, bone and joint infections, central nervous system infections, skin and soft tissue infections, intra-abdominal infections, burns, postoperative infections, complicated and recurrent urinary tract infections
    • Effective in infections caused by gentamicin and/or tobramycin-resistant strains of Gram-negative organisms
    • Effective in staphylococci infections
  • Pharmacology:
    • Semi-synthetic aminoglycoside antibiotic
    • Active against pseudomonas species, Escherichia coli, Proteus species, Providencia species, Klebsiella-Enterobacter species, Acinetobacter species, and Citrobacter freundii
    • Active against penicillinase and nonpenicillinase-producing Staphylococcus species including methicillin-resistant strains
  • Dosage:
    • Adult dosage of 15 mg/kg/day in two equally-divided doses
    • Neonates and premature children dosage with an initial loading dose of 10 mg/kg followed by 15 mg/kg/day in two equally divided doses
    • Elderly dosage adjusting as per impaired renal function
    • Increased adult dose for life-threatening infections and/or those caused by Pseudomonas
    • Dosage for urinary tract infections and impaired renal function
  • Administration:
    • Preferred intramuscular route for most infections
    • Intravenous route for life-threatening infections or when intramuscular route is not feasible
    • Intraperitoneal use as an irrigant after recovery from anesthesia in concentration of 0.25%
  • Interaction:
    • Concurrent administration with myorelaxants potentiate their effects
    • Avoid combination with other Aminoglycoside antibiotics and fast acting diuretics
    • Increased risk of ototoxicity with concurrent administration with cephalosporins or polymixins
  • Contraindications:
    • Contraindicated in patients with known hypersensitivity to Amikacin or any constituents of the injection
  • Side Effects:
    • Adverse effects include tinnitus, vertigo, reversible or irreversible deafness, skin rash, drug fever, headache, paraesthesia, nausea and vomiting
  • Pregnancy & Lactation:
    • Rapid crossing of the placenta into the fetal circulation and amniotic fluid
    • Potential risk of ototoxicity in the fetus
    • No information available regarding safety during breastfeeding
  • Precautions & Warnings:
    • High concentrations in the renal excretory system, requires patients to be well hydrated to minimize chemical irritation of the renal tubules
    • Monitoring of renal function during treatment is important
  • Use in Special Populations:
    • Safety and effectiveness in children or adolescents under 16 years not established
  • Overdose Effects:
    • Peritoneal or haemodialysis advised in the event of overdose or toxic reaction
  • Therapeutic Class:
    • Aminoglycosides
  • Storage Conditions:
    • Keep below 30°C, away from light & moisture
    • Keep out of the reach of children

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