Cordarone 200 mg (Tablet)

Title

• Cordarone Tablet
• Cordarone Injection

Categories

• Antiarrhythmic Medication
• Therapeutic Medication
• Cardiovascular Medication

Description

• Used for various serious arrhythmias of the heart
• Corrects abnormal rhythms of the heart
• Broad spectrum antiarrhythmic medication
• Causes blood vessels to dilate
• May be beneficial in congestive heart failure

Dosage

• Tablet: 200 mg 3 times daily for 1 week, then reduced to 200 mg twice daily or minimum required dosage to control arrhythmia
• Injection: Starting dose of 1000 mg over the first 24 hours, with specific infusion regimen
• Tablet should be taken with meals to minimize stomach upset

Indications

• Treatment of ventricular fibrillation
• Prophylaxis of ventricular tachycardia
• Used for atrial fibrillation and atrial flutter

Mode of Action

• Delays heart's electrical system recharging
• Prolongs electrical phase during which heart's muscle cells are electrically stimulated
• Slows speed of electrical conduction
• Reduces rapidity of firing of normal generator of electrical impulses in the heart
• Slows conduction through specialized electrical pathways
• Causes blood vessels to dilate

Interaction

• May interact with b blockers and calcium channel blockers resulting in slow heart rate
• Increases blood levels of Digoxin
• Increases Flecainide, Procainamide, and Quinidine concentrations
• Interacts with tricyclic antidepressants, Warfarin, and inhibits metabolism of Dextromethorphan

Contraindications

• Patients with cardiogenic shock
• Severe sinus-node dysfunction
• Second- or third-degree atrioventricular block
• Known hypersensitivity to the drug or its components

Side Effects

• Severe lung-related reactions
• Fatal liver toxicity
• Reversible corneal microdeposits
• Peripheral neuropathy and myopathy
• Bradycardia and conduction disturbances
• Phototoxicity, skin discoloration, hypothyroidism, hyperthyroidism
• Jaundice, hepatitis, cirrhosis, nausea, vomiting
• Metallic taste, tremor, sweating, vertigo, headache
• Sleeplessness, fatigue, alopecia, raised intracranial pressure
• Ataxia, rashes, vasculitis, renal involvement, thrombocytopenia, anemia

Pregnancy & Lactation

• Not recommended during pregnancy
• May cause hypo or hyperthyroidism in infants from oral use during pregnancy
• Safe use during lactation has not been established

Therapeutic Class

• Potassium channel blockers

Storage Conditions

• Keep below 30°C temperature
• Away from light & moisture
• Keep out of the reach of children

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