Trinil Plus (20 mg+10 mg+2.5 mg)/5 ml (Syrup)

Indications

• temporarily relieves symptoms due to common cold
• temporarily relieves symptoms due to hay fever
• relieves cough due to minor throat or bronchial irritation
• relieves runny nose
• relieves sneezing
• relieves itching of the nose or throat
• relieves itchy, watery eyes
• relieves nasal congestion
• reduces swelling of nasal passages

Pharmacology

• contains antitussive, decongestant, and antihistamine agents
• antitussive agent has a central action on the cough centre in the medulla
• decongestant shrinks blood vessels in the nasal passage
• antihistamine provides relief from histamine triggered conditions
• antihistamine is a potent competitive histamine H1-receptor antagonist with mild CNS depressant properties

Dosage

• adults & children 12 years and older: 1 teaspoonful (5 ml) every 4 hours
• children 6 to under 12 years: ½ teaspoonful (2.5 ml) every 4 hours
• children 2 to 6 years: to be used with caution and as advised by the physician
• not to be used in children below 2 years old

Administration

• can be taken with or without food
• liquid doses should be measured carefully using the provided measuring device

Interaction

• may interact with certain MAO inhibitors
• caution should be exercised when using with antihistamines applied to the skin, antispasmodics, beta blockers, drugs for Parkinson’s disease, guanethidine, certain inhaled anesthetics, methyldopa, reserpine, scopolamine, tricyclic antidepressants, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, narcotic pain relievers, psychiatric medicines

Contraindications

• should be avoided in patients with liver disease or asthma
• contraindicated in patients taking monoamine oxidase inhibitors
• contraindicated in patients with known hypersensitivity to specific ingredients
• contraindicated during acute attacks of asthma
• contraindicated in patients with severe hypertension or severe coronary artery disease

Side Effects

• may cause drowsiness
• may cause dizziness
• may cause constipation
• other side effects include GIT discomfort, transient hypertension, dry mouth, restlessness, palpitations, allergic reactions, toxic psychosis, blood dyscrasia

Pregnancy & Lactation

• use in pregnancy and lactation is best avoided

Precautions & Warnings

• may cause drowsiness
• patients should avoid driving or operating machinery if affected
• alcoholic drinks should be avoided while on this medication
• use with caution in patients with specific conditions such as epilepsy, prostatic hypertrophy, glaucoma, hepatic disease, hypertension, heart disease, diabetes, hyperthyroidism, stenosing peptic ulcer, pyloro-duodenal obstruction, or bladder neck obstruction
• consult a physician if symptoms do not improve within one week or are accompanied by high fever

Overdose Effects

• hospital admission is strongly advised in cases of overdose
• overdose may produce respiratory depression, paranoid psychosis, delusions, hallucinations, and convulsions
• treatment may include emptying the stomach by aspiration or gastric lavage, and using sedatives for nervous stimulation and convulsions
• severe overdose of phenylephrine hydrochloride may produce hypertension and associated reflex bradycardia, which may be treated with specific measures

Therapeutic Class

• combined cough suppressants

Storage Conditions

• keep out of the reach of children
• keep in a cool & dry place
• protect from light

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