MMF 500 mg (Tablet)

Unit Price: ৳ 65.00 (3 x 10: ৳ 1,950.00)
Strip Price: ৳ 650.00

Medicine Details

Category Details
Generic Mycophenolate mofetil
Company Beacon pharmaceuticals plc

Title

Mycophenolate Mofetil Tablets

Categories

  • Immunosuppressive Agent
  • Chemotherapy
  • Immunosuppressant

Description

Mycophenolate Mofetil is an immunosuppressive agent that inhibits inosine monophosphate dehydrogenase (IMPDH) to prevent acute organ rejection in transplant patients and for the induction and maintenance therapy of lupus nephritis.

Indications

  • Prophylaxis of acute organ rejection in renal, cardiac, and hepatic transplant patients
  • Treatment of first or refractory organ rejection in renal transplant patients
  • Induction and maintenance therapy for lupus nephritis patients

Mechanism of Action

Mycophenolate mofetil inhibits the de novo pathway of guanosine nucleotide synthesis by selectively and reversibly inhibiting IMPDH, leading to cytostatic effects on lymphocytes and decreased antibody production.

Pharmacodynamics

Mycophenolic acid, the active metabolite, inhibits the de novo synthesis of guanosine nucleotides required for DNA and RNA synthesis, particularly in B and T lymphocytes.

Dosage & Administration

  • Transplant patients:
    • Lupus nephritis patients:
      • Therapeutic drug monitoring: Recommended to prevent sub-therapeutic exposure

      Interactions

      • Antacids
      • Azathioprine
      • Cyclosporin
      • Rifampin
      • Sevelamer
      • Cholestyramine
      • Acyclovir
      • Metronidazole
      • Hormonal contraceptives

      Contraindications

      • Hypersensitivity to mycophenolic acid or its excipients
      • Pregnancy
      • Breastfeeding

      Side Effects

      • Diarrhea
      • Leukopenia
      • Sepsis
      • Gastrointestinal candidiasis
      • Urinary tract infection
      • Herpes simplex
      • Vomiting

      Pregnancy & Lactation

      Contraindicated during pregnancy and breastfeeding; safe use during labor and delivery not established

      Precautions & Warnings

      • Increased risk of viral infections and blood dyscrasias
      • Can cause serious GI tract complications and increase the risk of developing malignancies
      • Avoid live vaccines
      • Avoid blood donation during therapy

      Use in Special Populations

      • Geriatric population: May be at an increased risk of certain adverse events

      Overdose Effects

      Expected to result in over suppression of the immune system, increased susceptibility to infections, and bone marrow suppression

      Storage Conditions

      Store in a cool, dry place below 30°C and away from light, out of reach of children

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