Camlopril 10 mg+20 mg (Capsule)

Indications

• Treatment of hypertension
• Not indicated for initial therapy of hypertension

Pharmacology

• Inhibition of angiotensin-converting enzyme (ACE)
• Inhibition of calcium ion influx into vascular smooth muscle and cardiac muscle
• Peripheral arterial vasodilation
• Peak plasma concentrations reached at different times for Benazepril and Amlodipine
• Antihypertensive effect within 1 hour
• Peak reductions achieved 2-8 hours after dosing
• Once-daily doses efficacy

Dosage & Administration

• Effective doses for Amlodipine and Benazepril
• Initiation therapy criteria
• Dose titration guidance
• Replacement therapy option for patients receiving Amlodipine and Benazepril from separate tablets
• Recommended initial dose for specific patient groups

Interaction

• Interaction with diuretics
• Potassium supplements and potassium-sparing diuretics interaction
• Clinical trials with Amlodipine

Contraindications

• Contraindicated for patients hypersensitive to Benazepril or any other ACE inhibitor, or to Amlodipine

Side Effects

• Safety evaluation for at least 6 months
• Discontinuation reasons for therapy
• Common side effects
• Incidence of edema
• Rare side effects

Pregnancy & Lactation

• Pregnancy categories
• Discontinuation recommendation during pregnancy
• Excretion of Benazepril and Amlodipine in breast milk
• Recommendation for breastfeeding

Precautions & Warnings

• Caution in patients with severe renal disease
• Possible occurrence of hyperkalemia
• Use in patients with hepatic failure
• ACE inhibitor-induced cough
• Effects on hypotension during surgery/anesthesia
• Carcinogenicity, mutagenicity, and impairment of fertility

Use in Special Populations

• Clinical experience differences between the elderly and younger patients
• Safety and effectiveness in pediatric patients not established

Overdose Effects

• No reported human overdoses with any combination of Amlodipine and Benazepril
• Reports of human overdoses with Benazepril and other ACE inhibitors

Therapeutic Class

• Combined antihypertensive preparations

Storage Conditions

• Temperature and environmental storage requirements
• Protection from light and moisture
• Keep out of reach of children

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