Lonet 100 mg (Tablet)

Unit Price: ৳ 1.37 (10 x 10: ৳ 137.00)
Strip Price: ৳ 13.70

Medicine Details

Category Details
Generic Atenolol
Company Beximco pharmaceuticals ltd
Also available as
Lonet 50 mg tablet

Product Title

  • Atenolol Tablets

Categories

  • Medicine
  • Hypertension Management
  • Angina Pectoris Management
  • Acute Myocardial Infarction Management

Description

  • Atenolol is a beta-adrenoceptor blocking drug
  • Used in the management of hypertension, angina pectoris, and acute myocardial infarction
  • Initial dosage is 50 mg once daily, may be increased to 100 mg once daily for optimal effect

Dosage Form

  • Tablets

Color

  • White

Pregnancy Category

  • Category D

Lactation

  • Caution advised

Age Group

  • Adults
  • Elderly

Mode of Action

  • β1 selective (cardioselective) antagonist
  • Competitively blocks β1 (cardiac) receptors

Indications

  • Hypertension
  • Angina Pectoris
  • Acute Myocardial Infarction

Contraindications

  • Sinus bradycardia
  • Greater than first degree heart block
  • Cardiogenic shock
  • Overt cardiac failure
  • Hypersensitivity to atenolol
  • History of hypersensitivity to any of the drug's components

Precautions

  • Evaluation required for patients already on beta blockers before administration
  • Aggravates peripheral arterial circulatory disorders
  • Caution in patients with impaired renal function
  • Dose adjustment for elderly, renal-impaired patients

Pediatric Use

  • Dosage adjustment in cases of severe impairment of renal function

Storage

  • Do not use later than the expiry date
  • Keep out of reach of children
  • Dispensed only on prescription

Interaction

  • Additive effects with catecholamine-depleting drugs
  • Additive effects with calcium channel blockers
  • Severe effects when administered with disopyramide, amiodarone, or clonidine
  • Decreased hypotensive effects with prostaglandin synthase inhibiting drugs
  • Increased risk of severe allergic reaction with a history of anaphylaxis
  • Increased risk of bradycardia with concomitant use of digitalis glycosides

Side Effects

  • Bradycardia
  • Hypotension
  • Agranulocytosis
  • Allergic reactions
  • Central nervous system adverse effects
  • Gastrointestinal adverse effects
  • Skin rashes
  • Dry eyes

Overdose Effects

  • Lethargy
  • Respiratory drive disorder
  • Bradycardia
  • Congestive heart failure
  • Hypotension
  • Bronchospasm
  • Hypoglycemia

Drug Classes

  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

General Warnings

  • Adjust dosage based on clinical observations
  • Aggravates peripheral arterial circulatory disorders
  • Use with caution in impaired renal function patients

Use in Special Populations

  • Dosage adjustment for elderly and renal-impaired patients

Storage Conditions

  • Expiry date should be checked
  • Keep medication away from children
  • Dispense only with prescription

Pharmacology

  • Marks the most hydrophilic of the currently available β-blockers
  • Poor penetration of lipid cell membranes

Hematologic Effects

  • Agranulocytosis

Allergic Effects

  • Fever
  • Respiratory distress
  • Skin rashes

Central Nervous System Adverse Effects

  • Mental depression
  • Impaired cognition
  • Decreased performance

Gastrointestinal Adverse Effects

  • Mesenteric arterial thrombosis
  • Ischemic colitis

Miscellaneous Adverse Effects

  • Dry eyes
  • Erythematous rash

Specific Precautions

  • Caution in patients with impaired renal function
  • Dosage adjustment for elderly, renal-impaired patients

Age-related Dosage

  • Dose selection for elderly patients should be cautious

Special Dosage Instructions

  • Initial dosage is 50 mg once daily for hypertension and angina pectoris
  • Maximum dosage for renal-impaired patients is 50 mg daily for creatinine clearance 15-35 ml/min/1.73 m² and 25 mg daily for creatinine clearance <15 mL/min/1.73 m²

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