Ocupin 1% (Ophthalmic Ointment)

Indications

• Cycloplegic or mydriatic for refraction
• Desired dilatation of the iris or uveal tract
• Treatment to slow the progression of myopia in children

Composition

• Atropine Sulphate BP 10 mg/ml in 1% eye drops
• Atropine Sulphate USP 0.1 mg/ml in 0.01% eye drops
• Preservatives: Benzalkonium Chloride 0.01%, Sodium Perborate 0.01%

Pharmacology

• Suppression of myopia progression
• Action via binding to muscarinic receptors
• Changes in cell signaling proteins and enzymes
• Scleral remodeling or strengthening
• Reduction in axial length and vitreous chamber depth

Dosage & Administration

• 1% Eye drops: For uveitis, one drop three times daily; for refraction, one drop in the eyes twice daily for one or two days before examination, and one hour before examination
• 0.01% Eye drops: One drop to each eye at night

Interaction

• Avoid use with anticholinergics, antiglaucoma agents, potassium citrate, potassium supplements, carbachol, physostigmine, pilocarpine, and CNS medication

Contraindications

• Not to be used in the presence of angle closure glaucoma or suspected angle closure glaucoma
• Depth estimation of the anterior chamber should be performed prior to therapy initiation in glaucoma-susceptible patients

Side Effects

• Blurred vision
• Local irritation
• Follicular conjunctivitis
• Vascular congestion
• Oedema
• Exudate
• Contact dermatitis
• Photophobia

Pregnancy & Lactation

• Systemic absorption possible after ocular administration
• Distributed into breast milk in very small amounts
• May cause adverse effects in nursing infants

Precautions & Warnings

• Avoid use in children with severe systemic reaction to Ocupin
• Use with caution in children with Down’s syndrome, spastic paralysis, or brain damage
• Regular eye health clinical reviews recommended for long-term treatment planning
• Not to be used in children under 4 years of age

Overdose Effects

• Flush the eye with water and seek emergency medical attention
• Symptoms include headache, fast heartbeat, dry mouth and skin, unusual drowsiness, flushing

Therapeutic Class

• Mydriatic and Cycloplegic agents

Storage Conditions

• Store below 30°C in a dry place away from light
• Keep out of the reach of children
• Do not use after 1 month of opening

Related Brands

• Ocupin 1% (Ophthalmic Solution) - osl-pharma-limited
• Atrogen 1% (Ophthalmic Ointment) - general-pharmaceuticals-ltd
• Atrogen 1% (Ophthalmic Solution) - general-pharmaceuticals-ltd
• Mydri Atropine 1% (Ophthalmic Ointment) - reman-drug-laboratories-ltd
• Mydri Atropine 1% (Ophthalmic Solution) - reman-drug-laboratories-ltd