Vertinor 16 mg (Tablet)

Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00

Medicine Details

Indications

  • Meniere's disease
  • Meniere-like syndromes
  • vertigo
  • tinnitus
  • progressive loss of hearing
  • nausea
  • vomiting

Description

  • Histamine analog
  • improves circulation in the inner ear
  • pressure reduction on membranous labyrinth

Pharmacology

  • Acts as a histamine H1-receptor agonist
  • vasodilatory effect
  • reduction in endolymphatic pressure
  • reduces asymmetrical functioning of sensory vestibular organs
  • increases vestibulocochlear blood flow
  • increases turnover of histamine from postsynaptic histaminergic nerve receptors
  • antagonizes histamine H3-receptors
  • elevates neurotransmitter levels including serotonin

Dosage & Administration

  • Initial oral treatment 8 to 16mg three times daily
  • maintenance doses 24-48 mg daily
  • preferably taken with meals
  • dosage adjustment
  • no data for patients with hepatic impairment
  • no data for patients with renal impairment
  • limited data in the elderly
  • not recommended for use in children and adolescents below age 18

Interaction

  • No proven cases of hazardous interactions
  • potential interaction with ethanol
  • potentiation with salbutamol
  • mutual attenuation of effect with H1 antagonists

Contraindications

  • Phaeochromocytoma
  • hypersensitivity to the active substance

Side Effects

  • Generally well tolerated
  • gastrointestinal disturbances
  • headache
  • rashes
  • pruritus

Pregnancy & Lactation

  • Safety in human pregnancy not completely established
  • no known teratogenic effect in animals
  • assessment of potential benefits in pregnancy
  • excretion in breast milk
  • toxicity to the neonate not known

Precautions & Warnings

  • Caution in patients with peptic ulcer or history of peptic ulceration
  • caution in patients with bronchial asthma
  • caution in patients with urticaria, rashes, or allergic rhinitis
  • caution in patients with severe hypotension
  • patients with rare hereditary problems should not take this medicine
  • rare reports of drowsiness
  • advice on avoiding activities requiring concentration

Overdose Effects

  • Nausea
  • vomiting
  • dyspepsia
  • ataxia
  • seizures
  • serious complications in cases of intentional overdose
  • no specific antidote
  • gastric lavage and symptomatic treatment recommended

Therapeutic Class

  • Drugs used in Meniere's disease

Storage Conditions

  • Below 30°C temperature
  • away from light & moisture
  • keep out of the reach of children

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