Cabretol 200 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Carbamazepine |
| Company | Renata limited |
| Also available as |
Indications
- Partial and secondary generalized tonic-clonic seizures
- Primary generalized tonic-clonic seizures
- Trigeminal neuralgia
- Prophylaxis of bipolar disorder
Pharmacology
Carbamazepine depresses activity in the nucleus ventralis of the thalamus, reduces synaptic propagation of excitatory impulses or decreases summation of temporal stimulation leading to neural discharge by limiting influx of Na ions across cell membrane or other unknown mechanisms. It stimulates the release of antidiuretic hormone (ADH) and potentiates its action in promoting reabsorption of water.
Dosage & Administration
- Initial and maintenance dosage for different age groups
- Combination therapy recommendations
- Dosage for trigeminal neuralgia
- Meal considerations
Interaction
Galactorrhoea has been reported in few women on oral contraceptives within the first two months of Cabretol treatment. Hepatic enzyme inducers such as Cabretol and Phenytoin may interact with Cabretol by increasing its metabolism, requiring dosage adjustments.
Contraindications
- Atrioventricular block
- Bone marrow depression
- Porphyrias
- Allergy to tricyclic antidepressants
- Recent use of monoamine-oxidase inhibitor antidepressant (MAOI)
Side Effects
- Common side effects
- Most severe adverse reactions
- Increased sensitivity to the sun
- Use of sunscreen and protective clothing
Pregnancy & Lactation
Pregnancy category D. Carbamazepine and its epoxide metabolite are transferred to breast milk. Decision should be made whether to discontinue nursing or discontinue the drug.
Precautions & Warnings
- Dizziness and drowsiness
- Skin reactions
- Liver problems
- Impact on hormonal contraceptives
- Discontinuation precautions
- Caution for specific medical history
Therapeutic Class
- Primary anti-epileptic drugs
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.