Arilol 25 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Title
- Arilol Carvedilol Tablets
Categories
- Medicine
- Cardiovascular Drug
- Hypertension
- Angina Pectoris
- Congestive Heart Failure
Description
- Arilol is used in the treatment of mild, moderate, or severe heart failure of ischemic or cardiomyopathic origin in conjunction with other medications to reduce disease progression. It is also used in the treatment of hypertension and angina pectoris.
Indications
- Treatment of mild, moderate, or severe heart failure of ischemic or cardiomyopathic origin
- Reduction of cardiovascular death and hospitalization
- Usage in patients unable to tolerate ACE inhibitor
- Usage in patients not receiving digitalis, hydralazine, or nitrate therapy
Pharmacology
- Non-selective antagonism of β-adrenergic receptors
- α-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Used in the treatment of hypertension, angina pectoris, and congestive heart failure
DosageAdministration
- Initial dose of 12.5mg once daily for hypertension, increased to 25mg once daily
- Initial dose of 12.5mg twice daily for angina pectoris, increased to 25mg twice daily
- Initial dose of 3.125mg twice daily for heart failure, increased gradually up to maximum tolerable dose
Interaction
- Increased levels of digoxin when taken together
- 60% decrease in Cmax and AUC with rifampin
- No alteration in in vitro plasma protein binding of warfarin
- Potential potentiation of pressor reaction with clonidine
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without permanent pacemaker
- Cardiogenic shock
- Severe bradycardia
SideEffects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Peripheral oedema
- Dry mouth and eyes
- Impotence
- Allergic skin reactions
- Exacerbation of psoriasis
- Nasal stuffiness
- Wheezing
- Depressed mood
- Thrombocytopenia
- Leukopenia
PregnancyLactation
- Not recommended during breastfeeding and pregnancy
- Excretion in breast milk
- Crosses the placental barrier
PrecautionsWarnings
- Caution in hepatic impairment and heart failure
- Monitor clinical status after initiation and dose increases
- Ensure renal function and heart failure are not deteriorating before increasing dose
TherapeuticClass
- Alpha-adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
StorageConditions
- Keep below 30°C temperature
- Keep away from light and moisture
- Keep out of the reach of children