Dilapress 25 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Title
- Dilapress 25mg Tablet
Categories
- Cardiovascular Drugs
- Beta-adrenoceptor Blockers
- Hypertension Medications
- Heart Failure Medications
Description
- Dilapress is indicated for the treatment of mild, moderate, or severe heart failure of ischemic or cardiomyopathic origin, in conjunction with digitalis, diuretics, and ACE inhibitor, to reduce the progression of disease as evidenced by cardiovascular death, cardiovascular hospitalization, or the need to adjust other heart failure medications.
- Carvedilol is a cardiovascular drug whose main pharmacological action is non-selective antagonism of β-adrenergic receptors but which also possesses appreciable α-adrenergic antagonistic activity. It also has antiproliferative properties and is a scavenger of reactive free oxidant radicals. It is used in the treatment of hypertension, angina pectoris, and congestive heart failure.
- Dilapress dosage varies for hypertension, angina pectoris, and heart failure, with different initial doses and adjustments based on patient weight and condition.
- Dilapress may interact with drugs such as digoxin, rifampin, warfarin, and clonidine, affecting their levels or actions in the body.
- Carvedilol is contraindicated in patients with decompensated heart failure requiring intravenous inotropic therapy, bronchial asthma or related bronchospastic conditions, second or third-degree AV block, sick sinus syndrome (unless a permanent pacemaker is in place), cardiogenic shock, or severe bradycardia.
- Potential side effects of Dilapress include postural hypotension, dizziness, headache, fatigue, gastrointestinal disturbances, bradycardia, peripheral oedema, dry mouth, impotence, and disturbances of micturition.
- Carvedilol should not be used during pregnancy, lactation, or in children; caution is advised in hepatic impairment and in heart failure, and Dilapress should be stored below 30°C, away from light and moisture.
Dimensions
- Tablet size: Standard
Color Options
- White
Functions
- Heart failure treatment
- Hypertension treatment
- Angina pectoris treatment
Materials
- Carvedilol
Technical Specifications
- Non-selective antagonism of β-adrenergic receptors
- α-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
Dosage & Administration
- Initial dose for hypertension: 12.5 mg once daily, increased to 25 mg once daily after 2 days, with a maximum of 50 mg daily in single or divided doses.
- Recommended dose for angina pectoris: 12.5 mg twice daily for the first 2 days, followed by 25 mg twice daily, with a maximum daily dose of 50 mg in divided doses for elderly patients.
- Initial dose for heart failure: 3.125 mg twice daily (with food), with gradual increments to the highest tolerated dose.
Interaction
- Increased monitoring of digoxin levels recommended when used concomitantly with Dilapress.
- Pretreatment with rifampin may reduce Cmax and AUC of Dilapress.
- Dilapress does not alter the in vitro plasma protein binding of warfarin.
- β-receptor antagonists may potentiate the pressor reaction following the sudden withdrawal of treatment with clonidine.
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome (unless a permanent pacemaker is in place)
- Cardiogenic shock
- Severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastrointestinal disturbances
- Bradycardia
- Peripheral oedema
- Dry mouth
- Impotence
- Disturbances of micturition
Pregnancy & Lactation
- Not to be used during breast-feeding
- Safety and efficacy in children not established
- Should not be used during pregnancy
Precautions & Warnings
- Caution in hepatic impairment and in heart failure
- Monitor clinical status for 2-3 hours after initiation and after increasing each dose
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
Usability Features
- May be used in patients unable to tolerate an ACE inhibitor
- May be used in patients who are not receiving digitalis, hydralazine, or nitrate therapy
Safety Information
- No studies performed in lactating women; animal studies show carvedilol is excreted in breast milk
- No information on the safety and efficacy in neonates