Dilgard 25 mg (Tablet)
Unit Price: ৳ 8.05 (3 x 10: ৳ 241.50)
Strip Price: ৳ 80.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild, moderate or severe heart failure
- Reduction of disease progression
- Conjunction with digitalis, diuretics, and ACE inhibitor
- Use in patients unable to tolerate ACE inhibitor
Pharmacology
- Non-selective antagonism of beta-adrenergic receptors
- Alpha-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
Dosage & Administration
- Initial dose for hypertension: 12.5 mg once daily
- Maximum dose for hypertension: 50 mg daily
- Recommended dose for angina pectoris: 25 mg twice daily
- Dose escalation for heart failure: 3.125 mg to 25 mg twice daily
Interaction
- Increased levels of digoxin when taken together
- 60% decrease in Cmax and AUC with rifampin
- No alteration in in vitro plasma protein binding of warfarin
- Potentiation of pressor reaction with clonidine
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without a permanent pacemaker
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Bradycardia
- Peripheral oedema
- Dry mouth
- Impotence
- Disturbances of micturition
- Exacerbation of intermittent claudication
- Allergic skin reactions
- Depressed mood
Pregnancy & Lactation
- Should not be used during breastfeeding
- Crosses placental barrier
Precautions & Warnings
- Caution in hepatic impairment
- Monitoring clinical status in heart failure
- Monitoring renal function
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
Storage Conditions
- Keep below 30°C
- Away from light & moisture
- Keep out of the reach of children