Efepime 1 gm/vial (IM/IV Injection)

1 gm vial: ৳ 550.00

Medicine Details

Category Details
Generic Cefepime hydrochloride
Company Ziska pharmaceuticals ltd
Also available as
Efepime 500 mg injection Efepime 2 gm injection

Title

  • Cefepime 1 gm Injection
  • Efepime 500 mg Injection
  • Cefepime Powder for Injection
  • Cefepime IV Infusion
  • Cefepime IM Injection

Categories

  • Antibiotics
  • Fourth Generation Cephalosporins
  • Intravenous Antibiotics
  • Bactericidal Antibiotics
  • Prescription Medication

Form

  • Injection
  • Powder for Injection
  • IV Infusion

Dosage

  • 1 gm IV 12 hourly for 10 days
  • 2 gm IV 8 hourly for 7 days
  • 0.5-1 gm IV/IM 12 hourly for 7-10 days
  • 2 gm IV 12 hourly for 10 days
  • 50 mg/kg/dose, every 12 hours for pediatric patients up to 40 kg in weight

Indications

  • Treatment of moderate to severe pneumonia caused by susceptible microorganisms
  • Empiric therapy for febrile neutropenic patients
  • Treatment of uncomplicated and complicated urinary tract infections
  • Treatment of uncomplicated skin and skin structure infections
  • Treatment of complicated intra-abdominal infections

Mode of Action

  • Bactericidal action
  • Disrupts synthesis of peptidoglycan layer of bacterial cell walls

Interaction

  • Renal function should be monitored carefully when administered with aminoglycosides
  • Nephrotoxicity potential with concurrent administration of potent diuretics

Contraindications

  • Immediate hypersensitivity reactions to cefepime or cephalosporin class of antibiotics

Side Effects

  • Possible hypersensitivity reactions

Pregnancy & Lactation

  • Category B in pregnancy
  • Excretion in human breast milk in very low concentrations

Precautions & Warnings

  • Use in absence of proven or strongly suspected bacterial infection may increase risk of drug-resistant bacteria
  • Prolonged use may result in overgrowth of non-susceptible microorganisms
  • Associated with fall in prothrombin activity
  • Prescribed with caution in individuals with history of gastrointestinal disease

Use in Special Populations

  • Max dose for pediatric patients should not exceed recommended adult dose
  • Serious adverse events in geriatric patients with renal insufficiency
  • No dosage adjustment needed for impaired hepatic function
  • Dose adjustment required for impaired renal function

Overdose Effects

  • Careful observation and supportive treatment required for patients who receive an overdose
  • Hemodialysis recommended in the presence of renal insufficiency

Therapeutic Class

  • Fourth generation Cephalosporins

Reconstitution

  • Administered intravenously over approximately 30 minutes
  • Compatible with various IV infusion fluids and diluents for intramuscular administration

Storage Conditions

  • Do not use later than the date of expiry
  • Keep all medicines out of reach of children
  • To be dispensed only on prescription of a registered physician

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