Efepime 2 gm/vial (IV Injection)

2 gm vial: ৳ 1,100.00

Medicine Details

Category Details
Generic Cefepime hydrochloride
Company Ziska pharmaceuticals ltd
Also available as
Efepime 500 mg injection Efepime 1 gm injection

Title

  • Cefepime 1 gm Injection
  • Efepime 4th Generation Cephalosporin

Category

  • Prescription Medicine
  • Antibiotic
  • Intravenous (IV) Medicine

Indications

  • Treatment for moderate to severe pneumonia
  • Empiric treatment for febrile neutropenic patients
  • Treatment for uncomplicated and complicated urinary tract infections
  • Treatment for uncomplicated skin and skin structure infections
  • Treatment for complicated intra-abdominal infections

Pharmacology

  • Bactericidal action
  • Disruption of peptidoglycan layer in bacterial cell walls
  • Similar mode of action as other beta-lactam antibiotics

Dosage & Administration

  • Intravenous administration over approximately 30 minutes
  • Specific dosages for different types of infections
  • Different duration of treatment for different infections

Interaction

  • Need for careful monitoring if administered with high doses of aminoglycosides
  • Potential nephrotoxicity and ototoxicity with aminoglycoside antibiotics

Contraindications

  • Immediate hypersensitivity reactions to cefepime or cephalosporins
  • Contraindicated in patients with hypersensitivity to penicillin or other betalactum antibiotics

Side Effects

  • Potential for immediate hypersensitivity reactions

Pregnancy & Lactation

  • Pregnancy Category B
  • Excretion in human breast milk at very low concentrations
  • Caution advised for use in nursing women

Precautions & Warnings

  • Avoid use in absence of proven or strongly suspected bacterial infection
  • Risk of the development of drug-resistant bacteria
  • Potential for overgrowth of non-susceptible microorganisms
  • Association with fall in prothrombin activity
  • Caution in individuals with a history of gastrointestinal disease
  • Effect of arginine on glucose metabolism and serum potassium

Use in Special Populations

  • Dosage limitations for pediatric patients
  • Adverse events in geriatric patients with renal insufficiency
  • No dosage adjustment required for impaired hepatic function
  • Dosage adjustment for impaired renal function

Overdose Effects

  • Careful observation and supportive treatment for overdose
  • Recommendation for hemodialysis in the presence of renal insufficiency

Therapeutic Class

  • Fourth generation Cephalosporins

Reconstitution

  • IV administration compatibility with specific IV fluids
  • Intramuscular administration compatibility with specific diluents
  • Detailed instructions for reconstitution of different vial strengths

Storage Conditions

  • Expiry date adherence
  • Keep out of the reach of children
  • Dispensing only on prescription of a registered physician

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