Efepime 2 gm/vial (IV Injection)
2 gm vial: ৳ 1,100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefepime hydrochloride |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Title
- Cefepime 1 gm Injection
- Efepime 4th Generation Cephalosporin
Category
- Prescription Medicine
- Antibiotic
- Intravenous (IV) Medicine
Indications
- Treatment for moderate to severe pneumonia
- Empiric treatment for febrile neutropenic patients
- Treatment for uncomplicated and complicated urinary tract infections
- Treatment for uncomplicated skin and skin structure infections
- Treatment for complicated intra-abdominal infections
Pharmacology
- Bactericidal action
- Disruption of peptidoglycan layer in bacterial cell walls
- Similar mode of action as other beta-lactam antibiotics
Dosage & Administration
- Intravenous administration over approximately 30 minutes
- Specific dosages for different types of infections
- Different duration of treatment for different infections
Interaction
- Need for careful monitoring if administered with high doses of aminoglycosides
- Potential nephrotoxicity and ototoxicity with aminoglycoside antibiotics
Contraindications
- Immediate hypersensitivity reactions to cefepime or cephalosporins
- Contraindicated in patients with hypersensitivity to penicillin or other betalactum antibiotics
Side Effects
- Potential for immediate hypersensitivity reactions
Pregnancy & Lactation
- Pregnancy Category B
- Excretion in human breast milk at very low concentrations
- Caution advised for use in nursing women
Precautions & Warnings
- Avoid use in absence of proven or strongly suspected bacterial infection
- Risk of the development of drug-resistant bacteria
- Potential for overgrowth of non-susceptible microorganisms
- Association with fall in prothrombin activity
- Caution in individuals with a history of gastrointestinal disease
- Effect of arginine on glucose metabolism and serum potassium
Use in Special Populations
- Dosage limitations for pediatric patients
- Adverse events in geriatric patients with renal insufficiency
- No dosage adjustment required for impaired hepatic function
- Dosage adjustment for impaired renal function
Overdose Effects
- Careful observation and supportive treatment for overdose
- Recommendation for hemodialysis in the presence of renal insufficiency
Therapeutic Class
- Fourth generation Cephalosporins
Reconstitution
- IV administration compatibility with specific IV fluids
- Intramuscular administration compatibility with specific diluents
- Detailed instructions for reconstitution of different vial strengths
Storage Conditions
- Expiry date adherence
- Keep out of the reach of children
- Dispensing only on prescription of a registered physician