Co-Axet (125 mg+31.25 mg)/5 ml (Powder for Suspension)

70 ml bottle: ৳ 250.00

Medicine Details

Category Details
Generic Cefuroxime axetil clavulanic acid
Company Orion pharma ltd
Also available as
Co axet 250 mg tablet Co axet 500 mg tablet

Categories

  • Medicine
  • Antibiotic
  • Cephalosporin
  • Infection treatment
  • Bactericidal
  • Beta-lactamase inhibitor
  • Second generation
  • Oral Suspension
  • Therapeutic Class

Dosage

  • Adolescents and adults (13 years and older):
    • 250 mg b.i.d. for 5-10 days
    • 250-500 mg b.i.d. for 10 days
    • 250-500 mg b.i.d. for 5-10 days
    • 250-500 mg b.i.d. for 5-10 days
    • 250-500 mg b.i.d. for 10 days
    • 250-500 mg b.i.d. for 10 days
    • 250 mg b.i.d. for 7-10 days
    • 1000 mg b.i.d. Single dose
    • 250-500 mg b.i.d. for 5-10 days
    • 500 mg b.i.d. for 10-14 days
    • 500 mg b.i.d. for 20 days
  • Paediatric Patients (3 months to 12 years):
    • 20 mg/kg/day b.i.d for 5-10 days
    • 30 mg/kg/day b.i.d for 10 days
    • 30 mg/kg/day b.i.d for 10 days
    • 30 mg/kg/day b.i.d for 10 days

Color Options

  • N/A

Interaction

  • Concomitant administration:
    • Probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%
  • Effect of gastric acidity:
    • Reduces bioavailability of Cefuroxime

Contraindications

  • Known allergy to cephalosporin
  • Pseudomembranous Colitis

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal discomfort or pain
  • Overgrowth of nonsusceptible microorganisms
  • Renal dysfunction
  • Anaphylaxis
  • Angioedema
  • Pruritis
  • Rash
  • Serum sickness like urticaria

Pregnancy & Lactation

  • Avoidance in the first trimester:
    • If possible
  • Excretion into breast milk:
    • Small quantities
  • Caution for infant sensitization:
    • Should be kept in mind

Precautions & Warnings

  • Given with care to patients receiving concurrent treatment with potent diuretics
  • Patients with history of colitis

Storage Conditions

  • Below 30°C
  • Away from light and moisture

Pharmacology

  • Cefuroxime:
    • Bactericidal second generation cephalosporin antibiotic
    • Active against a wide range of Gram-positive and Gram-negative susceptible organisms
    • Inhibits bacterial cell wall synthesis
    • Interferes with the transpeptidation process
  • Clavulanic Acid:
    • Naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus
    • Irreversibly binds to beta-lactamase enzymes and inactivates them
    • Protects Cefuroxime from degradation by beta lactamase enzymes
    • Provides a solution for the treatment of bacterial infections caused by beta lactam resistant bacteria
  • Therapeutic Class:
    • Second generation Cephalosporins

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