Malorin 80 mg/5 ml (Syrup)
60 ml bottle: ৳ 12.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Chloroquine phosphate |
| Company | Albion laboratories limited |
Indications
- Treatment of malaria
- Prophylaxis and suppression of malaria
- Treatment of amoebic hepatitis and abscess
- Treatment of discoid and systemic lupus erythematosus
- Treatment of rheumatoid arthritis
Composition
- Tablet: Each film coated tablet contains Chloroquine Phosphate BP 250 mg equiv. to approx. 150 mg of Chloroquine base
- Syrup: Each 5 mL contains Chloroquine Phosphate BP 80 mg equiv. to approx. 50 mg of Chloroquine base
Pharmacology
- 4-aminoquinoline antimalarial and amoebicidal agent
- Used for the suppression and clinical cure of malaria due to susceptible strains of Plasmodium falciparum, P. ovale, P. vivax and P. malariae
- Rapidly acting blood schizontocide with some gametocytocidal activity
- Mechanism of action against blood schizonts remain unclear but may act by influencing haemoglobin digestion
- Rapid and almost complete absorption from the gastro-intestinal tract when given by mouth
Dosage & Administration
- Doses expressed in terms of chloroquine base
- Different dosage for the treatment of acute attack of malaria, clinical prophylaxis, hepatic amoebiasis, discoid and systemic lupus erythematosus, rheumatoid arthritis, management of photoallergic reactions, and porphyria cutanea tarda
Interaction
- Exhibits interaction with drugs like neostigmine, pyridostigmine, antacids, kaolin, cimetidine, ranitidine, quinine, mefloquine, amodiaquine, artemisinin, metronidazole, ampicillin
Contraindications
- Known or suspected chloroquine resistance in P. falciparum
- Hypersensitivity
- Retinal damage
- Concurrent therapy with hepatotoxic drugs
Side Effects
- Gastro-intestinal: Nausea, vomiting, and diarrhoea
- Psychological: Psychotic episodes, anxiety, and personality changes
- Visual disturbances: Blurred vision, difficulties in focusing, keratopathy, retinopathy
- Haematological: Aplastic anaemia, agranulocytosis, thrombocytopenia, and neutropenia
- Others: Loss of hair, bleaching of hair pigment, bluish black pigmentation, photosensitivity, tinnitus, reduced hearing, nerve deafness, uromyopathy, and myopathy
Pregnancy & Lactation
- Use during pregnancy should be avoided except in the suppression or treatment of malaria when benefit outweighs the possible hazard
- Consideration should be made for nursing infants from chloroquine
Precautions & Warnings
- Eyes should be examined before starting long-term treatment and monitored subsequently
- Visual disturbances may render patients unfit to take charge of vehicles or machinery
- Care is necessary in administering to patients with impaired liver or renal function, prophyria, psoriasis, or a history of epilepsy
- Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency should be observed for haemolytic anaemia during chloroquine treatment
Therapeutic Class
- Anti-malarial drugs
Storage Conditions
- Keep below 30°C temperature, away from light & moisture
- Keep out of reach of children