Lox-D 0.3%+0.1% (Ophthalmic Solution)

Indications

• Treatment of steroid responsive inflammatory ocular conditions
• Post-operative inflammation
• Ocular inflammation associated with infection
• Ear infections accompanied by inflammation
• Otitis externa
• Otitis media

Pharmacology

• Anti-inflammatory action
• Anti-allergic action
• Reduction of prostaglandin synthesis
• Inhibition of neutrophil infiltration
• Bactericidal action against gram-negative and gram-positive organisms
• Interference with DNA gyrase

Dosage & Administration

• 1 drop for eye every 4-6 hours
• Increased dosage for initial 24-48 hours
• 4 drops for ear 2 times daily for 7 days in pediatric patients with typanostomy tube
• 4 drops for ear 2 times daily for 7 days in acute otitis externa
• Pediatric use not established below 1 year

Interaction

• Elevation of plasma concentrations of theophylline
• Interference with the metabolism of caffeine
• Enhancement of effects of oral anticoagulant warfarin
• Transient elevations in serum creatinine in patients receiving cyclosporin concomitantly

Contraindications

• Hypersensitivity to any ingredient
• Herpes simplex and other viral conditions
• Mycosis
• Glaucoma
• Newborn babies
• Fungal diseases of ocular or auricular structures

Side Effects

• Ocular burning or discomfort
• Stinging
• Redness
• Itching
• Conjunctivitis/keratitis
• Periocular/facial edema
• Foreign body sensation
• Photophobia
• Blurred vision
• Tearing
• Dryness
• Eye pain
• Dizziness
• Elevation of intraocular pressure
• Optic nerve damage
• Posterior subcapsular cataract formation
• Delayed wound healing
• Ear pain
• Irritability
• Erythema

Pregnancy & Lactation

• Use during pregnancy if benefit justifies risk to the fetus
• Caution when used by nursing mothers

Precautions & Warnings

• Consider possibility of fungal infections after long-term steroid dosing
• Monitor for overgrowth of non-susceptible organisms
• Monitor for glaucoma, optic nerve damage, visual defects, and cataract formation
• Routinely monitor intraocular pressure

Therapeutic Class

• Aural steroid & antibiotic combined preparations

Storage Conditions

• Store in cool and dry place
• Away from light
• Keep out of reach of children
• Shake well before each use
• Use within 30 days after opening
• Close bottle tightly immediately after use

Related Brands

• Geflox-D 0.3%+0.1% (Ophthalmic Solution) - general-pharmaceuticals-ltd