Clozam 10 mg (Tablet)
Unit Price: ৳ 2.81 (10 x 10: ৳ 281.00)
Strip Price: ৳ 28.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobazam |
| Company | Navana pharmaceuticals ltd |
Indications
- acute anxiety
- chronic anxiety
- restlessness
- emotional instability
- sleep disturbances
- tension
- irritability
- psychovegetative disorders
- psychosomatic disorders
- cardiovascular disorders
- gastrointestinal disorders
- depression
- schizophrenia
- epilepsy
Pharmacology
- binds to GABA receptors
- increases chloride ionopore opening duration
- enhances GABA inhibitory effect
Dosage
- adjustable dosage
- treatment duration
- initial dose
- maintenance dose
- dosage adjustments for different age groups
- timing of doses
- reduced dosage after symptom improvement
- dosage spread throughout the day
- short duration of treatment
- gradual discontinuation of treatment
Administration
- whole or crushed tablet administration
- mixing with applesauce option
- can be taken with or without food
Interaction
- alcohol interaction
- interaction with CNS depressant drugs
- interaction with opioids
- interaction with anticonvulsants
- interaction with narcotic analgesics
- enhanced muscle relaxant effects
- CYP 2C19 inhibitors
- CYP 2D6 substrates
Contraindications
- hypersensitivity to clobazam
- myasthenia gravis
- severe respiratory insufficiency
- sleep apnoea syndrome
- severe impairment of liver function
- breastfeeding
- use in children between 6 months and 3 years
Side Effects
- decreased appetite
- irritability
- aggression
- restlessness
- sedation
- dizziness
- disturbance in attention
- headache
- nausea
- rash
- muscle spasms
- muscle weakness
- fatigue
- photosensitivity reaction
- weight changes
Pregnancy & Lactation
- not recommended in first trimester
- potential risk to fetus
- crosses placenta
- neonatal respiratory depression
- physical dependence in newborn
- not recommended in breastfeeding women
- informed consent for women of childbearing potential
Precautions & Warnings
- serious skin reactions
- respiratory depression
- muscle weakness
- renal and hepatic impairment
- increased risk of adverse reactions in elderly
- decrease in anticonvulsant efficacy
- CYP2C19 poor metabolizers
- suicidality risk
- CYP2C19 inhibitors interaction
Therapeutic Class
- Benzodiazepine hypnotics
Storage Conditions
- store below 30°C
- protect from light
- do not use after expiry date
- keep out of the reach of children