Dasatin 100 mg (Tablet)
Unit Price: ৳ 350.00 (1 x 30: ৳ 10,500.00)
Strip Price: ৳ 10,500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Dasatinib |
| Company | Jenphar bangladesh ltd |
Indications
- Treatment of newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase
- Treatment of chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with resistance or intolerance to prior therapy including Imatinib
- Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance or intolerance to prior therapy
- Treatment of pediatric patients 1 year of age and older with Ph+ CML in chronic phase
- Treatment of newly diagnosed Ph+ ALL in combination with chemotherapy
Pharmacology
- Inhibition of BCR-ABL, SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFRβ kinases
- Predicted to bind to multiple conformations of the ABL kinase
- Active in leukemic cell lines representing variants of imatinib mesylate-sensitive and resistant disease
- Metabolized primarily by CYP3A4 and involved enzymes
Dosage & Administration
- Recommended starting dosage of 100 mg for chronic phase CML in adults
- Recommended starting dosage of 140 mg for accelerated phase CML, myeloid or lymphoid blast phase CML, or Ph+ ALL in adults
- Different dosages based on body weight for pediatric patients
Interaction
- Coadministration with strong CYP3A4 inhibitors may increase concentrations and risk of toxicity
- Coadministration with strong CYP3A4 inducers may decrease concentrations and reduce efficacy
- Coadministration with gastric acid reducing agents may decrease concentrations
Contraindications
- Contraindicated in patients with known hypersensitivity to Dasatinib
Side Effects
- Myelosuppression
- Bleeding-related events
- Fluid retention
- Cardiovascular events
- Pulmonary arterial hypertension
- QT prolongation
- Severe dermatologic reactions
- Tumor lysis syndrome
- Effects on growth and development in pediatric patients
Pregnancy & Lactation
- Can cause fetal harm when administered to a pregnant woman
- Contraception advised for females of reproductive potential
- Breastfeeding not recommended
Precautions & Warnings
- Severe thrombocytopenia, neutropenia, and anemia
- Serious and fatal bleeding
- Fluid retention
- Cardiac dysfunction
- Pulmonary arterial hypertension
- Prolongation of QTc
- Severe mucocutaneous dermatologic reactions
- Tumor lysis syndrome
Overdose Effects
- Limited experience with overdose
- Severe myelosuppression and bleeding reported in isolated cases
Therapeutic Class
- Targeted Cancer Therapy
Storage Conditions
- Store below 30°C in a dry place
- Protect from light
- Keep out of the reach of children