HPC DS 500 mg/2 ml (IM Injection)
2 ml ampoule: ৳ 750.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Hydroxyprogesterone caproate |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Reduction of risk of preterm birth in women with singleton pregnancy
- Prevention of preterm labor in singleton pregnancy
Description
- Synthetic steroid hormone similar to medroxyprogesterone acetate and megestrol acetate, ester derivative of 17a-hydroxyprogesterone formed from caproic acid
Pharmacology
- Progesterone vital for regulation of female reproductive system
- Important for successful implantation of embryo and maintenance of pregnancy
- Acts by binding to progesterone receptors in uterus, ovaries, breasts, and central nervous system
- Receptors exist in 2 isoforms, PR-A and PR-B
- Anti-inflammatory effect blunts proinflammatory state and maintains uterine queiscence
Dosage & Administration
- Administer intramuscularly at a dose of 500mg or 250mg once weekly
- Begin treatment between 16 weeks, 0 days and 20 weeks, 6 days of gestation
- Continue administration once weekly until week 37 (through 36 weeks, 6 days) of gestation or delivery, whichever occurs first
- Injection procedure steps
Contraindications
- Thrombosis or thromboembolic disorders
- Known or suspected breast cancer or other hormone-sensitive cancer
- Undiagnosed abnormal vaginal bleeding unrelated to pregnancy
- Cholestatic jaundice of pregnancy
- Liver tumors, benign or malignant, or active liver disease
- Uncontrolled hypertension
Side Effects
- Injection site reactions (pain, swelling, pruritus, nodule)
- Hives
- Itching
- Nausea
- Diarrhea
- Symptoms of blood clots
- Allergic reactions
Pregnancy & Lactation
- Category B for pregnancy
- No adverse effects on breastfeeding performance or infant health
Precautions & Warnings
- Discontinue if thrombosis or thromboembolism occurs
- Monitor glucose tolerance in pre-diabetic and diabetic women
- Monitor fluid retention in women with specific conditions
- Monitor women with history of clinical depression
- Carefully monitor women with jaundice or hypertension
Use in Special Populations
- Not indicated for pediatric patients
- Not evaluated in women over 65 years of age
- Effect not evaluated in hepatic or renal impairment
Overdose Effects
- No adverse events reported
Therapeutic Class
- Hormone preparations for other uses
Storage Conditions
- Store at controlled room temperature between 15°C to 30°C, protect from light, keep out of reach of children