Andepram 5 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 14: ৳ 336.00)
Strip Price: ৳ 112.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Escitalopram oxalate |
| Company | Radiant pharmaceuticals ltd |
| Also available as |
Title
- Andepram
Categories
- Antidepressant
- Anxiolytic
- SSRI
- Anti-Depressant Drug
- Medication
Description
- Escitalopram is an orally administered selective serotonin reuptake inhibitor (SSRI)
- At least 100 fold more potent than the R-enantiomer with respect to inhibition of 5-HT reuptake
- Escitalopram is contraindicated in patients with known hypersensitivity to Escitalopram or Citalopram or any of the inactive ingredients of the drug product
Indications
- Treatment of major depressive episodes
- Treatment of panic disorder with or without agoraphobia
- Treatment of social anxiety disorder (social phobia)
- Treatment of generalised anxiety disorder
- Treatment of obsessive-compulsive disorder
Pharmacology
- SSRIs are less sedating and have fewer antimuscarinic and cardiotoxic effects than tricyclic antidepressants
- Escitalopram has no or very low affinity for serotonergic or other receptors including alpha- and beta-adrenergic Dopamine, Histamine, Muscarinic and benzodiazepine receptors
Dosage
- Usual dosage is 10 mg once daily for major depressive episodes
- An initial dose of 5 mg is recommended for the first week before increasing the dose to 10 mg daily for panic disorder with or without agoraphobia
- Safety of daily doses above 20 mg has not been demonstrated
Administration
- Escitalopram should generally be administered once daily, morning or evening with or without food
Interaction
- SSRI or related antidepressants should not be started until 2 weeks after stopping an MAOI
- Conversely, an MAOI should not be started until at least a week after an SSRI or related antidepressant has been stopped
Contraindications
- Concomitant use of escitalopram in patients taking monoamine oxidase/pimozide is contraindicated
Side Effects
- Gastrointestinal effects (dose-related and fairly common include nausea, vomiting, dyspepsia, abdominal pain, diarrhea, constipation)
- Anorexia with weight loss (increased appetite and weight gain also reported) and hypersensitivity reactions including rash, urticaria, angioedema, anaphylaxis, arthralgia, myalgia, and photosensitivity
- Other side-effects include dry mouth, nervousness, anxiety, headache, insomnia, tremor, dizziness, asthenia, hallucinations, drowsiness, convulsions, galactorrhea, sexual dysfunction, urinary retention, sweating, hypomania or mania, movement disorders and dyskinesias, visual disturbances
Pregnancy & Lactation
- When treating a pregnant woman with Escitalopram during the third trimester, the physician should carefully consider the potential risks and benefits of treatment
Precautions & Warnings
- SSRIs should be used with caution in patients with epilepsy (avoid if poorly controlled, discontinue if convulsions develop)
- Caution is advised in patients with severely reduced renal function (CLCR less than 30 ml/min)
- Caution and extra careful dose titration is advised in patients with severely reduced hepatic function
Use in Special Populations
- Andepram should not be used in the treatment of children and adolescents under the age of 18 years
- Dosage adjustment is not necessary in patients with mild or moderate renal impairment
Overdose Effects
- Symptoms seen in a reported overdose of escitalopram include symptoms mainly related to the central nervous system (ranging from dizziness, tremor, and agitation to rare cases of serotonin syndrome, convulsion, and coma)
Therapeutic Class
- SSRIs & related anti-depressant drugs
Storage Conditions
- Store below 30°C temperature and protect from light & moisture
- Keep the medicine out of the reach of children