Triginal MR 35 mg (Tablet (Modified Release))

Unit Price: ৳ 10.00 (3 x 14: ৳ 420.00)

Strip Price: ৳ 140.00

Medicine Details

Category	Details
Generic	Trimetazidine dihydrochloride
Company	Radiant pharmaceuticals ltd

Indications

Add-on therapy for stable angina pectoris
Symptomatic treatment in adults
Inadequately controlled by first-line antianginal therapies
Intolerant to first-line antianginal therapies

Pharmacology

First 3-keto acyl CoA thiolase inhibitor
Metabolic anti-ischemic agent
Inhibits fatty acid pathway
Inhibits 3-keto acyl CoA thiolase enzyme
Transfers oxygen to glucose pathway
Aerobic oxidation of glucose
Prevents angina pectoris

Dosage & Administration

Recommended dose of Trimetazidine is 35 mg twice daily
20 mg tablet thrice daily during meals
Assess benefit after three months
Discontinue if no treatment response

Interaction

No reported drug interactions
No interaction with beta-blockers
No interaction with calcium antagonists
No interaction with nitrates
No interaction with heparin
No interaction with hypolipidemic agents
No interaction with digitalis preparation

Contraindications

Hypersensitivity to active substance
Hypersensitivity to excipients
Parkinson’s disease
Parkinsonian symptoms
Tremors
Restless legs movement disorders
Severe renal impairment

Side Effects

Dizziness
Headache
Abdominal pain
Diarrhoea
Dyspepsia
Nausea
Vomiting
Rash
Pruritus
Urticaria
Asthenia

Pregnancy & Lactation

No data on use in pregnant women
Animal studies show no harmful effects on reproductive toxicity
Preferable to avoid use during pregnancy
Unknown excretion in human milk
Risk to newborns/infants cannot be excluded
Should not be used during breastfeeding

Precautions & Warnings

Not a curative treatment for angina attacks
Not an initial treatment for unstable angina pectoris
Not a treatment for myocardial infarction

Therapeutic Class

Other Anti-anginal & Anti-ischaemic drugs

Storage Conditions

Keep in a dry place away from light and heat
Keep out of the reach of children

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