Favirest 200 mg (Tablet)

Indications

• Treatment of novel or re-emerging pandemic influenza virus infections

Description

• Favirest is approved for manufacture and sale in Japan as an influenza antiviral.
• It selectively inhibits the RNA polymerase of the influenza virus, an enzyme required for viral replication once human host cells are infected.
• It is believed that Favirest may be effective in treating COVID-19.

Pharmacology

• Favipiravir is a new antiviral drug against influenza.
• It selectively inhibits RNA polymerase of the influenza virus, preventing replication of the influenza virus.
• Effective against all types and sub-types of human influenza A, B, and C viruses in vitro.

Dosage & Administration

• Usual adult dosage is 1600 mg of Favipiravir administered orally twice daily on Day 1, followed by 600 mg orally twice daily from Day 2 to Day 5.
• Total treatment duration should be 5 days.

Interaction

• In animal studies, decreased RBC production and increases in liver function parameters.
• Toxicity information regarding Favirest in humans is not readily available.

Contraindications

• Favipiravir is contraindicated for pregnant women and women who may possibly be pregnant.

Side Effects

• Most common side effects are Diarrhea and increase of blood uric acid levels.

Pregnancy & Lactation

• Favipiravir may cause delayed development or death of embryos during the early stage of pregnancy. Should not be given during pregnancy.

Precautions & Warnings

• Favirest should not be given in pregnant women.
• Caution should be taken for hepatic and renal impaired patients.
• Use as per the direction of a registered Physician.

Use in Special Populations

• Favirest is only approved as an experimental drug.
• Still a lot of studies are needed about its efficacy and toxic reactions and use in children.

Overdose Effects

• In animal studies, decreased RBC production, increases in liver function parameters, increased vacuolization in hepatocytes.
• Toxicity information regarding Favirest in humans is not readily available.

Therapeutic Class

• Anti-viral drugs

Storage Conditions

• Keep below 30°C temperature, protected from light & moisture.
• Keep out of the reach of children.

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