Zo-MUPS 40 mg (MUPS Tablet)
Unit Price: ৳ 16.50 (3 x 10: ৳ 495.00)
Strip Price: ৳ 165.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Esomeprazole mups preparation |
| Company | Everest pharmaceuticals ltd |
| Also available as |
Title
- Zo-MUPS 40 mg MUPS Tablet
Categories
- Proton Pump Inhibitor
- Gastric Ulcer Medication
- Acid Reflux Medication
- Digestive System Medication
- Pharmaceutical Product
Description
- Multiple-Unit Pellet System (MUPS) technology
- Greater bioavailability
- Uniform emptying of micro pellets from stomach into small intestine
- Rapid dissolution of enteric coating and drug release
- Combination of fast acting and sustained action
- Uniform drug release
- Once daily dosing
- Better and more uniform drug absorption
- Reduction in esophageal residence time
- Minimization of fluctuation in plasma concentration of drug
- Uniform gastric emptying
- Consistent and controlled pharmacological action
- Reduction in inter- and intra-subject variability in drug absorption
Indications
- Gastro-esophageal Reflux Disease (GERD)
- Risk reduction in NSAID associated gastric ulcer
- H. pylori eradication (Triple therapy)
- Zollinger-Ellison syndrome and idiopathic hypersecretion
Composition
- Esomeprazole MUPS 20 Tablet: Each MUPS tablet contains 20 mg Esomeprazole
- Esomeprazole MUPS 40 Tablet: Each MUPS tablet contains 40 mg Esomeprazole
Pharmacology
- Inhibition of gastric acid by blocking the proton pump
Dosage
- Adult (≥18 years) - Erosive esophagitis: 40 mg once daily for 4 weeks
- Children & adolescents (12-18 years) - Erosive esophagitis: 40 mg once daily for 4 weeks
- Adult (≥18 years) - Maintenance of healing of erosive esophagitis: 20 mg once daily
- Children & adolescents (12-18 years) - Maintenance of healing of erosive esophagitis: 20 mg once daily
- Adult (≥18 years) - Risk reduction in NSAID associated gastric ulcer: 20 mg once daily for 4-8 weeks
- Adult (≥18 years) - H. pylori eradication: 20 mg twice daily for 7 days
- Children & adolescents (12-18 years) - H. pylori eradication: 20 mg twice daily for 7 days
- Adult (≥18 years) - Zollinger-Ellison syndrome and idiopathic hypersecretion: 40-80 mg twice daily
- Children 1-11 years - Erosive esophagitis: Weight <20 kg: 10 mg once daily for 8 weeks, Weight ≥20 kg: 10 mg or 20 mg once daily for 8 weeks
- Children 1-11 years - Maintenance of healing of erosive esophagitis: 10 mg once daily
Administration
- Tablets should be swallowed whole with liquid
- Dispersal in non-carbonated water permissible
- Stir until the tablets disintegrate and drink the liquid with the pellets immediately or within 30 minutes
- Pellets must not be chewed or crushed
Interaction
- Metabolism in the liver by CYP2C19 and CYP3A4
- Inhibition of CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
- No clinically relevant interactions with specified drugs
- Potential interference with CYP2C19 and drug absorption
- Increase in plasma levels of diazepam
- Interference with gastric acid-dependent drug bioavailability
Contraindications
- Known hypersensitivity to any of the formulation
Side effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy and lactation
- Caution advised
- Unknown presence in human breast milk
Precautions and warnings
- Use with caution in severe liver dysfunction and severe renal impairment
- Slight increase in risk of hip, wrist, and spine fracture
- Potential long-term impact on bone health
- Risk of mineral deficiency
Storage conditions
- Store below 25ºC
- Protection from light
- Keep out of reach of children
Chemical structure
- Molecular Formula: C17H19N3O3S
- Chemical Structure: [link to image]
Commonly asked questions
- Description of Zo-MUPS 40 mg MUPS Tablet
- Explanation of MUPS Tablet
- Uses of Zo-MUPS 40 mg MUPS Tablet
- Common side effects of Zo-MUPS 40 mg MUPS Tablet
- Safety during pregnancy and breastfeeding
- Onset of action of Zo-MUPS 40 mg MUPS Tablet
- Quick Tips for using Zo-MUPS 40 mg MUPS Tablet