Zo-MUPS 40 mg (MUPS Tablet)

Unit Price: ৳ 16.50 (3 x 10: ৳ 495.00)
Strip Price: ৳ 165.00

Medicine Details

Category Details
Generic Esomeprazole mups preparation
Company Everest pharmaceuticals ltd
Also available as
Zo mups 20 mg tablet

Title

  • Zo-MUPS 40 mg MUPS Tablet

Categories

  • Proton Pump Inhibitor
  • Gastric Ulcer Medication
  • Acid Reflux Medication
  • Digestive System Medication
  • Pharmaceutical Product

Description

  • Multiple-Unit Pellet System (MUPS) technology
  • Greater bioavailability
  • Uniform emptying of micro pellets from stomach into small intestine
  • Rapid dissolution of enteric coating and drug release
  • Combination of fast acting and sustained action
  • Uniform drug release
  • Once daily dosing
  • Better and more uniform drug absorption
  • Reduction in esophageal residence time
  • Minimization of fluctuation in plasma concentration of drug
  • Uniform gastric emptying
  • Consistent and controlled pharmacological action
  • Reduction in inter- and intra-subject variability in drug absorption

Indications

  • Gastro-esophageal Reflux Disease (GERD)
  • Risk reduction in NSAID associated gastric ulcer
  • H. pylori eradication (Triple therapy)
  • Zollinger-Ellison syndrome and idiopathic hypersecretion

Composition

  • Esomeprazole MUPS 20 Tablet: Each MUPS tablet contains 20 mg Esomeprazole
  • Esomeprazole MUPS 40 Tablet: Each MUPS tablet contains 40 mg Esomeprazole

Pharmacology

  • Inhibition of gastric acid by blocking the proton pump

Dosage

  • Adult (≥18 years) - Erosive esophagitis: 40 mg once daily for 4 weeks
  • Children & adolescents (12-18 years) - Erosive esophagitis: 40 mg once daily for 4 weeks
  • Adult (≥18 years) - Maintenance of healing of erosive esophagitis: 20 mg once daily
  • Children & adolescents (12-18 years) - Maintenance of healing of erosive esophagitis: 20 mg once daily
  • Adult (≥18 years) - Risk reduction in NSAID associated gastric ulcer: 20 mg once daily for 4-8 weeks
  • Adult (≥18 years) - H. pylori eradication: 20 mg twice daily for 7 days
  • Children & adolescents (12-18 years) - H. pylori eradication: 20 mg twice daily for 7 days
  • Adult (≥18 years) - Zollinger-Ellison syndrome and idiopathic hypersecretion: 40-80 mg twice daily
  • Children 1-11 years - Erosive esophagitis: Weight <20 kg: 10 mg once daily for 8 weeks, Weight ≥20 kg: 10 mg or 20 mg once daily for 8 weeks
  • Children 1-11 years - Maintenance of healing of erosive esophagitis: 10 mg once daily

Administration

  • Tablets should be swallowed whole with liquid
  • Dispersal in non-carbonated water permissible
  • Stir until the tablets disintegrate and drink the liquid with the pellets immediately or within 30 minutes
  • Pellets must not be chewed or crushed

Interaction

  • Metabolism in the liver by CYP2C19 and CYP3A4
  • Inhibition of CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
  • No clinically relevant interactions with specified drugs
  • Potential interference with CYP2C19 and drug absorption
  • Increase in plasma levels of diazepam
  • Interference with gastric acid-dependent drug bioavailability

Contraindications

  • Known hypersensitivity to any of the formulation

Side effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy and lactation

  • Caution advised
  • Unknown presence in human breast milk

Precautions and warnings

  • Use with caution in severe liver dysfunction and severe renal impairment
  • Slight increase in risk of hip, wrist, and spine fracture
  • Potential long-term impact on bone health
  • Risk of mineral deficiency

Storage conditions

  • Store below 25ºC
  • Protection from light
  • Keep out of reach of children

Chemical structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: [link to image]

Commonly asked questions

  • Description of Zo-MUPS 40 mg MUPS Tablet
  • Explanation of MUPS Tablet
  • Uses of Zo-MUPS 40 mg MUPS Tablet
  • Common side effects of Zo-MUPS 40 mg MUPS Tablet
  • Safety during pregnancy and breastfeeding
  • Onset of action of Zo-MUPS 40 mg MUPS Tablet
  • Quick Tips for using Zo-MUPS 40 mg MUPS Tablet

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