Ajardy M 5 mg+500 mg (Tablet)
Unit Price: ৳ 15.00 (4 x 8: ৳ 480.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Ziska pharmaceuticals ltd |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Adjunct to diet and exercise
- Use in patients insufficiently controlled on maximally tolerated dose of Metformin alone
- Use in combination with other medicinal products for diabetes
- Use in patients already being treated with the combination of Empagliflozin and Metformin separately
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduction of renal reabsorption of filtered glucose
- Lowering of renal threshold for glucose
- Increase in urinary glucose excretion
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized based on effectiveness and tolerability
- Twice daily with meals
- Gradual dose escalation to reduce gastrointestinal side effects
- Maximum recommended daily doses of Metformin Hydrochloride and Empagliflozin
- Extended-release formulations available
- Dosing adjustment for renal impaired patients
- Not recommended for pediatric patients under 18 years of age
Interaction
- Diuretics
- Insulin or Insulin Secretagogues
- Positive Urine Glucose Test
- Drugs that Reduce Metformin Clearance
- Carbonic Anhydrase Inhibitors
- Drugs Affecting Glycemic Control
- Alcohol
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Diabetic pre-coma
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
- Hepatic impairment
- Acute alcohol intoxication
- Alcoholism
Side Effects
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia
- Vaginal moniliasis
- Vulvovaginitis
- Balanitis
- Urinary tract infection
- Thirst
- Taste disturbance
- Pruritus
- Rash
- Increased urination
- Increased serum lipids
- Volume depletion
- Urticaria
- Dysuria
- Increased blood creatinine/Glomerular filtration rate
- Increased haematocrit
- Diabetic ketoacidosis
Pregnancy & Lactation
- Potential risk to fetus
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic Acidosis
- Hypotension
- Ketoacidosis
- Acute kidney injury & impairment in renal function
- Urosepsis, Pyelonephritis, Fournier's gangrene & Genital mycotic infections
- Hypoglycemia
- Vitamin B12 Deficiency
- Increased LDL-C
- Macrovascular Outcomes
Overdose Effects
- No toxicity seen with single/multiple doses of Empagliflozin
- Hypoglycemia not seen with Metformin
- Lactic acidosis a medical emergency
- Treatment should be initiated based on clinical status
- Haemodialysis for removal of lactate and Metformin
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children