Maxfer 1 gm/20 ml (IV Injection or Infusion)

20 ml vial: ৳ 1,300.00

Medicine Details

Category Details
Generic Ferric carboxymaltose
Company Eskayef pharmaceuticals ltd
Also available as
Maxfer 500 mg injection

Indications

  • Treatment of iron deficiency anaemia in adult patients
  • Intolerance to oral iron or unsatisfactory response to oral iron
  • Non-dialysis dependent chronic kidney disease

Description

  • Colloidal iron (III) hydroxide in complex with Carboxymaltose
  • Carbohydrate polymer that releases iron

Dosage & Administration

  • Stepwise approach for Ferric Carboxymaltose posology
  • Determination of individual iron need based on body weight and haemoglobin level
  • Calculation and administration of iron dose(s)
  • Maximum individual iron dose(s) not to exceed specified limits
  • Post-iron repletion assessments by the clinician

Interaction

  • Formal drug interaction studies not performed

Contraindications

  • Hypersensitivity to active substance or excipients
  • Serious hypersensitivity to other parenteral iron products
  • Anaemia not attributed to iron deficiency
  • Evidence of iron overload or disturbances in iron utilization

Side Effects

  • Infrequent and mild side effects
  • Nausea, headache, dizziness, hypertension, injection site reactions
  • Nausea, alanine aminotransferase increased, hypophosphatemia
  • Hypersensitivity, dysgeusia, tachycardia, hypotension, flushing
  • Dyspnoea, dyspepsia, abdominal pain, constipation, diarrhea
  • Pruritus, urticaria, erythema, rash, myalgia, back pain
  • Arthralgia, muscle spasms, Pyrexia, fatigue, chest pain
  • Peripheral edema, chills, aspartate aminotransferase increased
  • Gamma glutamyl transferase increased, blood lactate dehydrogenase increased
  • Blood alkaline phosphatase increased, anaphylactoid reactions
  • Loss of consciousness, anxiety, phlebitis, syncope
  • Presyncope, bronchospasm, flatulence, angioedema
  • Pallor and face edema, rigors, malaise, influenza like illness

Pregnancy & Lactation

  • No adequate and well-controlled trials in pregnant women
  • Benefit/risk evaluation required before use during pregnancy
  • Unlikely risk to the breast-fed child based on limited data

Precautions & Warnings

  • Serious hypersensitivity reactions reported
  • Patients may present with shock, hypotension, loss of consciousness
  • Hypertension, transient elevations in systolic blood pressure
  • Clinically stable monitoring post-administration
  • Laboratory Test Alterations in the 24 hours following administration

Use in Special Populations

  • Limitations in haemodialysis-dependent chronic kidney disease patients
  • Not recommended in children under 14 years

Overdose Effects

  • Excessive dosages may lead to iron accumulation
  • Monitoring of iron parameters such as serum ferritin and transferrin saturation
  • Consideration of iron chelator if iron accumulation has occurred

Therapeutic Class

  • Parenteral Iron Preparations

Storage Conditions

  • Store in cool (below 30°C) & dry place, away from light
  • Do not freeze
  • Keep out of the reach of children

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