Glimitus M 1 mg+500 mg (Tablet (Extended Release))

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Glimepiride metformin
Company Ziska pharmaceuticals ltd
Also available as
Glimitus m 2 mg tablet

Indications

  • Adjunct to diet and exercise in type 2 diabetes mellitus patients
  • Monotherapy or replacement of combination therapy of glimepiride and metformin

Pharmacology

  • Sulfonylurea antidiabetic agent
  • Stimulates release of insulin
  • Reduces basal hepatic glucose production
  • Increases peripheral tissue sensitivity to insulin
  • Decreases intestinal absorption of glucose

Dosage

  • Governed by desired blood glucose level
  • Lowest dosage sufficient for metabolic control
  • Regular measurement of glucose levels in blood and urine
  • Maximum recommended daily doses
  • Starting dose not to exceed existing doses of glimepiride or metformin

Administration

Must be swallowed whole and not crushed or chewed

Interaction

  • Glimepiride:
    • Metabolized by cytochrome P450 2C9 (CYP2C9)
    • Potentiation and weakening of blood-glucose-lowering effect with various drugs
    • Exhibits unpredictable interaction with alcohol
  • Metformin:
    • Concomitant use not recommended with alcohol
    • Discontinue prior to imaging procedure with iodinated contrast agents
    • Requires precautions when used in combination with certain medicinal products
    • Substrate of organic cation transporters (OCT)

Contraindications

  • Glimepiride:
    • Hypersensitivity to glimepiride or metformin
    • Pregnant or breastfeeding women
  • Metformin:
    • Hypersensitivity to metformin
    • Acute metabolic acidosis, severe renal failure, hepatic insufficiency, alcohol intoxication, lactation

Side Effects

  • Glimepiride:
    • Hypoglycemia
    • Visual impairment
    • Gastrointestinal symptoms
    • Changes in blood picture
    • Hepatitis and liver enzyme elevation
    • Allergic reactions
    • Weight gain
  • Metformin:
    • Gastrointestinal symptoms
    • Metallic taste
    • Vitamin B12 absorption decrease
    • Lactic acidosis
    • Hemolytic anemia
    • Reduction of thyrotropin level

Pregnancy & Lactation

  • Glimepiride: Not recommended during pregnancy or breastfeeding
  • Metformin: Avoid use during pregnancy, caution in lactation

Precautions & Warnings

  • Glimepiride: Increased risk of hypoglycemia in initial weeks of treatment, careful monitoring required
  • Metformin: Regular monitoring of thyroid-stimulating hormone (TSH) levels, potential decrease in vitamin B12 levels

Use in Special Populations

  • Children: Insufficient data for pediatric use
  • Renal impairment:
    • Assessment of glomerular filtration rate (GFR) before initiation
    • Dose adjustments based on GFR levels

Overdose Effects

  • Glimepiride: May lead to severe life-threatening hypoglycemia, requires immediate medical attention
  • Metformin: May lead to lactic acidosis, a medical emergency

Therapeutic Class

Combination Oral hypoglycemic preparations

Storage Conditions

Cool and dry place, protected from light

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