Monotate 20 mg (Tablet)

Indications

• Prevention and treatment of angina pectoris due to coronary artery disease

Pharmacology

• Relaxation of vascular smooth muscle
• Dilatation of peripheral arteries and veins
• Reduction of left ventricular end-diastolic pressure
• Reduction of pulmonary capillary wedge pressure
• Reduction of systemic vascular resistance
• Dilatation of the coronary arteries

Dosage & Administration

• Usual oral dose of 1 tablet (20 mg) 2 times daily
• Maintenance doses ranging from 20 mg to 120 mg
• Suitable dose of 10 mg (1/2 tablet) for lower dosage

Interaction

• Contraindicated with phosphodiesterase inhibitors
• Contraindicated with riociguat
• Vasodilating effects may be additive with other vasodilators
• Marked symptomatic orthostatic hypotension when used with calcium channel blockers

Contraindications

• Allergy to isosorbide mononitrate
• Concomitant use with phosphodiesterase inhibitors
• Concomitant use with riociguat

Side Effects

• Headache
• Feelings of dizziness
• Hypotension

Pregnancy & Lactation

• Pregnancy Category B
• Reproduction studies in rats and rabbits
• Caution when administered to a nursing woman

Precautions & Warnings

• Severe hypotension may occur
• Caution in hypotensive patients
• Aggravation of angina caused by hypertrophic cardiomyopathy
• Tolerance occurrence in industrial workers with long-term exposure
• Daily headaches may accompany treatment
• Light-headedness on standing, especially after alcohol consumption

Overdose Effects

• Symptoms: Hypotension, throbbing headache, tachycardia
• Treatment: Placing patients in recumbent position, administering fluids

Therapeutic Class

• Nitrates: Coronary vasodilators

Storage Conditions

• Store at 20°-30°C

Related Brands

• Monotate 50 mg (Tablet) - sun-pharmaceutical-bangladesh-ltd