Livacol 10 mg (Tablet)
Unit Price: ৳ 55.00 (1 x 10: ৳ 550.00)
Strip Price: ৳ 550.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Obeticholic acid |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Treatment of primary biliary cholangitis (PBC) without cirrhosis
- Treatment of PBC with compensated cirrhosis without evidence of portal hypertension
- Can be used in combination with ursodeoxycholic acid (UDCA)
- Can be used as monotherapy for patients unable to tolerate UDCA
Pharmacology
- Obeticholic acid is an agonist for Farnesoid X Receptor (FXR)
- Key regulator of bile acid, inflammatory, fibrotic and metabolic pathways
- Decreases intracellular hepatocyte concentrations of bile acids
- Increases transport of bile acids out of the hepatocytes
Dosage & Administration
- Start with a dosage of 5 mg once daily for the first 3 months
- Increase to a maximum dosage of 10 mg once daily if needed
- Monitoring recommended for safety and treatment response
- Management strategies for intolerable pruritus
Interaction
- Interacts with bile acid binding resins
- Interacts with warfarin
- May increase exposure to CYP1A2 substrates with narrow therapeutic index
- Inhibitors of BSEP should be avoided
Contraindications
- Decompensated cirrhosis
- Compensated cirrhosis with evidence of portal hypertension
- Complete biliary obstruction
Side Effects
- Pruritus
- Fatigue
- Stomach pain and discomfort
- Rash
Pregnancy & Lactation
- Limited human data on use during pregnancy
- No information on presence in human milk
- Considerations for breastfeeding mothers
Precautions & Warnings
- Risk of hepatic decompensation and failure
- Severe pruritus management strategies
- Reduction in HDL-C levels observed
- Monitoring serum lipid levels during treatment
Use in Special Populations
- Pediatric use not established
- Geriatric use observations
- Hepatic impairment considerations
Overdose Effects
- Dose-dependent increase in hepatic adverse reactions
- Observation and supportive care recommended
Therapeutic Class
- Farnesoid X Receptor Agonists
Storage Conditions
- Store below 30°C
- Store in a dry place
- Protect from light
- Keep out of children's reach