Levetam 250 mg (Tablet)

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)

Strip Price: ৳ 150.00

Medicine Details

Category	Details
Generic	Levetiracetam
Company	Eskayef pharmaceuticals ltd
Also available as	Levetam 500 mg tablet Levetam xr 500 mg tablet

Indications

Monotherapy for partial-onset seizures in adults and adolescents from 16 years of age with newly diagnosed epilepsy
Adjunctive therapy for partial-onset seizures in adults, adolescents, children, and infants from 1 month of age with epilepsy
Treatment of myoclonic seizures in adults and adolescents from 12 years of age with Juvenile Myoclonic Epilepsy
Treatment of primary generalized tonic-clonic seizures in adults and adolescents from 12 years of age with Idiopathic Generalised Epilepsy

Mechanism

The precise mechanism(s) by which Levetam exerts its antiepileptic effect is unknown. It showed minimal activity in certain tests and protection against secondarily generalized activity from focal seizures induced by certain convulsants.

Dosage

Recommended starting dose for adults and adolescents from 16 years of age is 250 mg twice daily, increased to 500 mg twice daily after two weeks
Maximum dose is 1500 mg twice daily for adults

Administration

The film-coated tablets must be taken orally, swallowed with sufficient quantity of liquid, and may be taken with or without food. The daily dose is administered in two equally divided doses.

Interaction

No influence on serum concentrations of existing antiepileptic medicinal products
Concomitant administration with methotrexate has been reported to decrease methotrexate clearance
Decreased Levetam efficacy reported when concomitantly administered with osmotic laxative macrogol

Contraindications

Hypersensitivity to the active substance or other pyrrolidone derivatives or to any of the excipients

Side Effects

Most common adverse reactions include somnolence, asthenia, infection, dizziness in adults
Fatigue, aggression, nasal congestion, decreased appetite, irritability in pediatric patients

Pregnancy & Lactation

Not recommended during pregnancy and breastfeeding

Precautions & Warnings

Dose adjustment may be required in patients with renal impairment
Rare cases of decreased blood cell counts reported
Patients should be monitored for signs of depression and suicidal ideation and behaviors

Use in Special Populations

Elderly: Dose adjustment recommended in elderly patients with compromised renal function
Renal impairment: Daily dose must be individualized according to renal function

Overdose Effects

Somnolence, agitation, aggression, depressed level of consciousness, respiratory depression, and coma were observed with Levetam overdoses
No specific antidote for Levetam

Therapeutic Class

Adjunct anti-epileptic drugs

Storage Conditions

Store at a cool temperature not exceeding 25°C in a dry place, protected from light