Neurocet 500 mg/5 ml (IV Infusion)

5 ml ampoule: ৳ 40.00 (1 x 5: ৳ 200.00)

Medicine Details

Category Details
Generic Levetiracetam
Company Incepta pharmaceuticals ltd
Also available as
Neurocet 250 mg tablet Neurocet 500 mg tablet Neurocet 500 mg oral solution Neurocet xr 750 mg tablet Neurocet xr 500 mg tablet

Therapeutic Class

  • Adjunct anti-epileptic drugs

Indications

  • Treatment of partial-onset seizures with or without secondary generalization
  • Monotherapy in adults and adolescents from 16 years of age with newly diagnosed epilepsy
  • Adjunctive therapy in adults, adolescents, children, and infants from 1 month of age with epilepsy
  • Treatment of myoclonic seizures in adults and adolescents from 12 years of age with Juvenile Myoclonic Epilepsy
  • Treatment of primary generalized tonic-clonic seizures in adults and adolescents from 12 years of age with Idiopathic Generalised Epilepsy

Description

  • Precise mechanism(s) of action is unknown
  • Minimal activity in submaximal stimulation and threshold tests
  • Protection observed against secondarily generalized activity from focal seizures induced by pilocarpine and kainic acid
  • Inhibition of burst firing without affecting normal neuronal excitability

Dosage

  • Recommended starting dose of 250 mg twice daily for adults and adolescents from 16 years of age
  • Initial therapeutic dose of 500 mg twice daily for adults (≥18 years) and adolescents (12 to 17 years) weighing 50 kg or more
  • Maximum dose of 1500 mg twice daily
  • Not adapted for use in infants and children under the age of 6 years
  • Oral solution is preferred for pediatric population

Administration

  • Oral administration with a sufficient quantity of liquid
  • Administered in two equally divided doses
  • Film-coated tablets

Interaction

  • No influence on serum concentrations of existing antiepileptic medicinal products
  • Concomitant administration with probenecid and methotrexate
  • Decreased efficacy with concurrent use of osmotic laxative macrogol
  • Minimal alteration by food, slightly reduced absorption rate

Contraindications

  • Hypersensitivity to the active substance or other pyrrolidone derivatives or to any of the excipients

Side Effects

  • Most common adverse reactions include somnolence, asthenia, infection, dizziness
  • Pediatric patients may experience fatigue, aggression, nasal congestion, decreased appetite, irritability

Pregnancy & Lactation

  • Not recommended during pregnancy and in women of childbearing potential not using contraception
  • Excreted in human breast milk, breastfeeding not recommended unless clinically necessary
  • No impact on fertility detected in animal studies

Precautions & Warnings

  • Dose adjustment may be required for patients with renal impairment
  • Rare cases of decreased blood cell counts reported
  • Monitoring for signs of depression and suicidal ideation and behaviors recommended
  • Tablet formulation not adapted for use in infants and children under the age of 6 years

Use in Special Populations

  • Adjustment of the dose recommended in elderly patients with compromised renal function
  • Daily dose must be individualized according to renal function

Overdose Effects

  • Observation of somnolence, agitation, aggression, depressed level of consciousness, respiratory depression, and coma
  • No specific antidote available, treatment is symptomatic

Storage Conditions

  • Store at a cool temperature (not exceeding 25°C) and dry place, protected from light

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