Ligend 5 mg (Tablet)
Unit Price: ৳ 15.00 (2 x 10: ৳ 300.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin |
| Company | Euro pharma ltd |
Title
- Ligend 5 mg Tablet
Categories
- Medicine
- Diabetes Treatment
Description
- Ligend is indicated in the treatment of type 2 diabetes mellitus to improve glycaemic control in adults.
- Linagliptin is an inhibitor of DPP-4 (dipeptidyl peptidase-4), an enzyme that degrades the incretin hormones GLP-1 (glucagon like peptide-1) and GIP (glucose dependent insulinotropic polypeptide).
- Linagliptin 5 mg once daily. If added to metformin, the dose of metformin should be maintained and linagliptin administered concomitantly.
- Ligend is a weak competitive and a weak to moderate mechanism-based inhibitor of CYP isozyme CYP3A4, but does not inhibit other CYP isozymes.
- There may be hypoglycaemia, nasopharyngitis, cough and pancreatitis in combination with metformin and sulfonylurea.
- Pregnancy category B. There are no adequate and well controlled studies in pregnant women.
- Dipeptidyl Peptidase-4 (DPP-4) inhibitor
- Keep in a dry place away from light and heat. Keep out of the reach of children.
- Molecular Formula: C25H28N8O2
Indications
- Treatment of type 2 diabetes mellitus
- Improves glycaemic control in adults
- As monotherapy in patients inadequately controlled by diet and exercise alone
- As combination therapy with metformin
- In combination with a sulphonylurea and metformin
- No dose adjustment required for patients with renal impairment
- Can be taken with or without a meal at any time of the day
Pharmacology
- Inhibitor of DPP-4 enzyme
- Increases concentrations of active incretin hormones
- Stimulates release of insulin from pancreatic beta cells
- Decreases secretion of glucagon from pancreatic alpha cells
Dosage & Administration
- 5 mg once daily
- If added to metformin, maintain metformin dose
- Can be taken with or without a meal
- Consider lower dose of sulphonylurea when used in combination
Interaction
- Weak competitive and a weak to moderate mechanism-based inhibitor of CYP isozyme CYP3A4
- Low risk for clinically meaningful interactions with other medicinal products
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
Side Effects
- Hypoglycaemia
- Nasopharyngitis
- Cough
- Pancreatitis
Pregnancy & Lactation
- Pregnancy category B
- Use during pregnancy only if clearly needed
- Unknown passage into breast milk
Precautions & Warnings
- Hypersensitivity to the active substance or to any of the excipients
Therapeutic Class
- Dipeptidyl Peptidase-4 (DPP-4) inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C25H28N8O2
Commonly Asked Questions
- Used for the treatment of type 2 diabetes mellitus
- To be taken till improvement in health conditions is observed
- Should be taken in the dosage as prescribed by the doctor
- Should be taken after food
- Need to be kept in a cool dry place and in its original packaging