Xarelta 15 mg (Tablet)

Unit Price: ৳ 35.00 (1 x 14: ৳ 490.00)
Strip Price: ৳ 490.00

Medicine Details

Indications

  • Prevention of atherothrombotic events after Acute Coronary Syndrome (ACS)
  • Reduction of risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation
  • Treatment and prevention of deep vein thrombosis (DVT) & pulmonary embolism (PE)
  • Prophylaxis of DVT after knee or hip replacement surgery

Pharmacology

  • Highly selective direct factor Xa inhibitor
  • Interrupts intrinsic and extrinsic pathway of blood coagulation cascade
  • Does not inhibit thrombin or platelets

Dosage & Administration

  • Recommended doses for different conditions and patient profiles
  • May be taken with or without food

Interaction

  • Concomitant use with specific drugs increases exposure and pharmacodynamic effects
  • Co-administration with certain drugs decreases efficacy
  • Increased risk of bleeding with other specific drug classes

Contraindications

  • Known hypersensitivity to Rivaroxaban or excipients
  • Active pathological bleeding

Side Effects

  • Increased chance of bleeding
  • Spinal or epidural hematoma
  • Increased risk of stroke after discontinuation in nonvalvular atrial fibrillation

Pregnancy & Lactation

  • Pregnancy category C drug
  • No established dosing for pregnant women
  • Unknown excretion in human milk
  • Safety and efficacy not established in breastfeeding women

Precautions & Warnings

  • Risk of thrombotic events with early discontinuation
  • Increased risk of fatal bleeding in the presence of specific risk factors
  • Monitoring of neurological impairment in neuraxial anesthesia
  • Not recommended in specific patient profiles

Overdose Effects

  • May lead to hemorrhage
  • Systemic exposure not further increased at single doses >50 mg
  • No specific antidote available
  • Consideration of activated charcoal for reducing absorption

Therapeutic Class

  • Oral Anticoagulants

Storage Conditions

Cool and dry place below 30°C, protected from light, keep away from children

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