Megenox 200 mg/5 ml (Oral Suspension)
100 ml bottle: ৳ 500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Megestrol acetate |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Palliative treatment of advanced carcinoma of the breast
- Palliative treatment of advanced carcinoma of the endometrium
- Treatment of anorexia
- Treatment of cachexia
- Treatment of unexplained significant weight loss in patients with AIDS
- Treatment of unexplained significant weight loss in patients with cancer
Pharmacology
- Synthetic, antineoplastic and progestational drug
- Inhibition of pituitary gonadotrophin production
- Decrease in estrogen secretion
- Modification of action of other steroid hormones
- Direct cytotoxic effect on tumor cells
- Estrogen secretion
- Plasma levels measurement method dependent
- Peak plasma concentrations 2 to 3 hours after a single oral dose
- Plasma half-life of 33 to 38 hours
Dosage & Administration
- 160 mg/day for breast cancer
- 40-320 mg/day in divided doses for endometrial carcinoma
- At least 2 months of continuous treatment for efficacy determination
- Recommended adult initial dosage of 800 mg/day (20 ml/day) for oral suspension
Interaction
- Possible interactions with concomitant medications
- Fluid retention caution with high dosages or prolonged periods
Contraindications
- Hypersensitivity to Megestrol Acetate or any component of the formulation
- Known or suspected pregnancy
Side Effects
- Weight gain
- Increased appetite
- Thromboembolic phenomena including thrombophlebitis and pulmonary embolism
- Glucocorticoid effects
- Nausea
- Dyspnea
- Hyperglycemia
- Glucose intolerance
- Alopecia
- Hypertension
- Carpal tunnel syndrome
- Mood changes
- Hot flashes
- Malaise
- Asthenia
- Lethargy
- Sweating
- Rash
Pregnancy & Lactation
- Pregnancy Category D
- Not recommended during the first four months of pregnancy
- Small amounts excreted in mother's milk
- Potential adverse effects on the newborn
Precautions & Warnings
- Close surveillance for recurrent or metastatic cancer patients
- Use caution in patients with a history of thromboembolic disease
- Exacerbation of preexisting diabetes with increased insulin requirements
Use in Special Populations
- Safety and effectiveness not established in pediatric patients
- Insufficient data for patients 65 years and older
Overdose Effects
- No serious unexpected side effects reported up to 1600 mg/day
Storage Conditions
- Store below 30°C
- Store in a cool, dry place away from light and moisture
- Keep out of reach of children