Eben-DS 400 mg (Chewable Tablet)

Unit Price: ৳ 4.00 (25's pack: ৳ 100.00)

Medicine Details

Category Details
Generic Albendazole
Company Edruc limited
Also available as
Eben 200 mg suspension

Indications

  • Single and mixed infestations of hookworm, roundworm, threadworm, whipworm, strongyloides, tapeworm, opisthorchi, hydatid

Description

  • Benzimidazole anthelmintic
  • Active against most nematodes and some cestodes
  • Used in the treatment of intestinal nematode infections
  • Used in higher doses in the treatment of hydatid disease
  • Exhibits vermicidal, ovicidal, and larvicidal activity
  • Inhibitory effect on tubulin polymerization resulting in loss of cytoplasmic microtubules

Pharmacology

  • Broad spectrum anthelmintic
  • Blocks glucose uptake in susceptible helminths
  • Depletes energy level of helminths
  • Immobilization and subsequent parasite death
  • Extensively metabolized, probably in the liver
  • Poorly absorbed from the gastrointestinal tract
  • Rapid extensive first-pass metabolism
  • Principal metabolite albendazole sulphoxide has anthelmintic activity with a plasma half-life of about 8.5 hrs
  • Excreted in the urine together with other metabolites

Dosage & administration

  • Recommended doses for adults, children over 2 years, children of 1-2 years
  • Not recommended for children under 1 year
  • Treatment of strongyloidiasis, taeniasis, and hydatid disease
  • Treatment regimen for cystic echinococcosis and alveolar echinococcosis
  • Treatment of giardiasis

Interaction

  • No reported pharmacodynamic or pharmacokinetic interactions

Contraindications

  • Not normally used in neonates
  • Possible reduction of dose in children weighing less than 10 kg
  • Not recommended during pregnancy or for women thought to be pregnant
  • No evidence to suggest dose alteration in renal, hepatic, or cardiac failure

Side effects

  • Gastrointestinal disturbances
  • Headache
  • Dizziness
  • Changes in liver enzymes
  • Reversible alopecia (rare)
  • Rash
  • Fever
  • Blood disorders including leucopenia and pancytopenia reported
  • Allergic shock if cyst leakage
  • Convulsion and meningism in cerebral disease

Pregnancy & lactation

  • US FDA Pregnancy category C
  • Avoided in pregnancy and lactation unless potential benefits outweigh possible risks to the fetus

Precautions & warnings

  • Blood counts and liver function tests before treatment and twice during each cycle
  • Breastfeeding
  • Exclude pregnancy before starting treatment
  • Constant medical supervision with regular monitoring of serum-transaminase concentrations, leucocyte, and platelet counts during treatment of echinococcosis

Therapeutic class

  • Anthelmintic

Storage conditions

  • Keep in a dry place
  • Away from light and heat
  • Keep out of the reach of children

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