Baricit 4 mg (Tablet)
Unit Price: ৳ 30.00 (1 x 10: ৳ 300.00)
Strip Price: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Baricitinib |
| Company | Delta pharma ltd |
| Also available as |
Indications
- Treatment of adult patients with moderate to severely active Rheumatoid Arthritis
- Inadequate response to one or more tumor necrosis factor (TNF) antagonist therapies
Pharmacology
- Selective and reversible inhibitor of Janus kinase JAK1 and JAK2
- Modulation of signaling pathways by inhibiting JAK1 and JAK2 enzymatic activity
Dosage & Administration
- Recommended dose of 2 mg once daily
- Can be used as monotherapy or in combination with Methotrexate or other DMARDs
- Oral administration with or without food
Pediatric Use
Safety and effectiveness not established
Geriatric Use
Care should be taken in dose selection for elderly patients
Hepatic Impairment
No dose adjustment for patients with mild or moderate hepatic impairment
Renal impairment
Not recommended for use in patients with estimated GFR of less than 60 mL/min/I .73 m2
Interaction
- Increased exposure when co-administered with strong OAT3 inhibitors
- Not studied in combination with other JAK inhibitors or with biologic DMARDs
Contraindications
- Avoid initiation or interrupt in patients with anemia (hemoglobin less than 8 g/dL)
- Avoid initiation or interrupt in patients with lymphopenia (Absolute Lymphocyte Count less than 500 cells/mm3)
- Avoid initiation or interrupt in patients with neutropenia (Absolute Neutrophil Count less than 1000 cells/mm3)
Side Effects
- Most commonly reported adverse reactions: increased LDL cholesterol (33.6%)
- upper respiratory tract infections (14.7%)
- nausea (2.8%)
Pregnancy & Lactation
- Contraindicated during pregnancy
- No information available on the presence in human milk
Precautions & Warnings
- Avoid use in patients with active, serious infection, including localized infections
- Not to be given to patients with active TB
- Consider risks and benefits prior to initiating therapy in patients with a known malignancy
- Use with caution in patients at increased risk of thrombosis
- Use with caution in patients at increased risk for gastrointestinal perforation
- To be dispensed only by the prescription of a registered physician
Overdose Effects
Patients should be monitored for signs and symptoms of adverse reactions. Those developing adverse reactions should receive appropriate treatment
Therapeutic Class
Immunosuppressant
Storage Conditions
- Store at or below 30°C temperature
- Keep away from light and wet place
- Keep out of reach of children