Lacicard 4 mg (Tablet)

Indications

• Treatment of hypertension alone
• Treatment of hypertension in combination with other antihypertensive agents

Pharmacology

• Inhibition of calcium influx into smooth muscle cells
• Competitive inhibition of voltage-dependent calcium 'L' channels

Dosage & Administration

• Initial dose of 2 mg once daily
• Dose can be increased to 4 mg and then to 6 mg after 3 to 4 weeks
• Should be taken preferably in the morning

Interaction

• Plasma concentration may be increased by simultaneous administration of cimetidine
• No specific pharmacodynamic interaction problems identified in studies with common antihypertensive agents or with digoxin, tolbutamide, or warfarin

Contraindications

• Hypersensitivity to any ingredient
• Cardiogenic shock
• Unstable angina
• Aortic stenosis
• Avoid within 1 month of myocardial infarction
• Impaired left ventricular function

Side Effects

• Flushing
• Palpitation
• Edema
• Headache
• Dizziness
• Rarely gastro-intestinal disturbances
• Gum hyperplasia
• Mood disturbances
• Asthenia
• Polyuria
• Muscle cramps
• Skin rash

Pregnancy & Lactation

• No data on safety of Lacidipine in human pregnancy
• No evidence of teratogenic effect in animal study
• Likely excretion of Lacidipine (or its metabolites) into breast milk
• Lacidipine should not be used during pregnancy or lactation

Precautions & Warnings

• Cardiac conduction abnormalities
• Poor cardiac reserves
• Hepatic impairment
• Withdraw if ischemic pain occurs shortly after initiating treatment or if cardiogenic shock develops
• Avoid grapefruit juice

Use in Special Populations

• No data on safety or efficacy of Lacicard in neonates
• Treatment with Lacicard not evaluated in Children
• Severe hepatic impairment: Reduce dose

Overdose Effects

• Symptoms: Prolonged peripheral vasodilation associated with hypotension and tachycardia
• Symptomatic and supportive treatment for management

Therapeutic Class

• Calcium-channel blockers

Storage Conditions

• Store in a cool and dry place
• Protect from light and moisture
• Keep out of the reach of children

Related Brands

• Lacicard 2 mg (Tablet) - aristopharma-ltd