Carnovas 5 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Nebivolol hydrochloride
Company Beximco pharmaceuticals ltd
Also available as
Carnovas 25 mg tablet Carnovas 10 mg tablet

Indications

  • Hypertension
  • Treatment of essential hypertension
  • Chronic heart failure (CHF)
  • Treatment of stable mild and moderate chronic heart failure in elderly patients

Pharmacology

  • β adrenergic receptor blocking agent
  • Inhibition of both β1 and β1 adrenergic receptors
  • Lack of intrinsic sympathomimetic and membrane stabilizing activity
  • Decreased heart rate
  • Decreased myocardial contractility
  • Diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers
  • Suppression of renin activity
  • Vasodilation and decreased peripheral vascular resistance
  • Metabolized by glucuronidation and hydroxylation by CYP2D6
  • Mean peak plasma concentrations occur approximately 1.5 to 4 hours post-dosing
  • In vitro human plasma protein binding of approximately 98% to albumin
  • Predominantly metabolized via direct glucuronidation
  • Concomitant administration with digoxin and warfarin

Dosage & Administration

  • Recommended starting dose of 5 mg once daily
  • Can be increased up to 40 mg at 2-week intervals
  • Should be individualized to the needs of the patient
  • Unlikely to benefit from a more frequent dosing regimen

Interaction

  • Use with care when myocardial depressants or inhibitors of AV conduction are used concurrently
  • Contraindicated with other β-blockers
  • Cautious use with CYP2D6 inhibitors

Contraindications

  • Severe bradycardia
  • Heart block greater than first degree
  • Cardiogenic shock
  • Decompensated cardiac failure
  • Sick sinus syndrome without a permanent pacemaker
  • Severe hepatic impairment
  • Hypersensitivity to any component of this product

Side Effects

  • Headache
  • Nausea
  • Bradycardia

Precautions & Warnings

  • Abrupt Cessation of Therapy
  • Cardiac Failure
  • Angina and Acute Myocardial Infarction
  • Bronchospastic Diseases
  • Anesthesia and Major Surgery
  • Diabetes and Hypoglycemia
  • Thyrotoxicosis
  • Peripheral Vascular Disease
  • Non-dihydropyridine Calcium Channel Blockers

Use in Special Populations

  • Impaired Renal Function
  • Impaired Hepatic Function
  • Risk of Anaphylactic Reactions

Therapeutic Class

  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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