Carnovas 10 mg (Tablet)

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Nebivolol hydrochloride
Company Beximco pharmaceuticals ltd
Also available as
Carnovas 25 mg tablet Carnovas 5 mg tablet

Indications

  • Hypertension
  • Treatment of essential hypertension
  • Chronic heart failure (CHF)
  • Treatment of stable mild and moderate chronic heart failure in elderly patients.

Pharmacology

  • Beta adrenergic receptor blocking agent
  • Inhibition of beta1 and beta1 adrenergic receptors
  • Lack of intrinsic sympathomimetic and membrane stabilizing activity
  • Decreased heart rate
  • Decreased myocardial contractility
  • Diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers
  • Suppression of renin activity
  • Vasodilation and decreased peripheral vascular resistance
  • Metabolized by glucuronidation and hydroxylation by CYP2D6
  • Plasma protein binding of approximately 98% to albumin
  • Absorption similar to an oral solution
  • Mean peak plasma concentrations approximately 1.5 to 4 hours post-dosing
  • Metabolized predominantly via direct glucuronidation of parent
  • 38% to 67% recovery in urine and feces after administration
  • No significant changes in pharmacokinetics when administered with digoxin or warfarin

Dosage & Administration

  • Recommended starting dose of 5 mg once daily
  • Dose can be increased at 2-week intervals up to 40 mg
  • Administration with or without food
  • More frequent dosing regimen unlikely to be beneficial

Interaction

  • Use with care when myocardial depressants or AV conduction inhibitors are used concurrently
  • Not to be combined with other beta-blockers
  • Cautious use with catecholamine-depleting drugs
  • Caution when co-administered with CYP2D6 inhibitors

Contraindications

  • Severe bradycardia
  • Heart block greater than first degree
  • Cardiogenic shock
  • Decompensated cardiac failure
  • Sick sinus syndrome (unless a permanent pacemaker is in place)
  • Severe hepatic impairment
  • Hypersensitivity to any component of the product

Side Effects

  • Headache
  • Nausea
  • Bradycardia

Precautions & Warnings

  • Patients advised against abrupt discontinuation of therapy
  • Severe exacerbation of angina and occurrence of myocardial infarction and ventricular arrhythmias reported
  • Administration cautiously in patients with compensated congestive heart failure
  • Not studied in patients with angina pectoris or recent MI
  • Patients with bronchospastic diseases should not receive beta-blockers
  • Close monitoring during anesthesia and major surgery
  • Possible masking of hypoglycemia manifestations
  • Possible masking of clinical signs of hyperthyroidism
  • Possible precipitation or aggravation of symptoms of arterial insufficiency in patients with peripheral vascular disease
  • Caution when used concomitantly with non-dihydropyridine calcium channel blockers

Use in Special Populations

  • Caution in patients with severe renal impairment
  • Caution in patients with moderate hepatic impairment
  • Contraindicated in patients with severe hepatic impairment
  • Increased reactivity to repeated challenges in patients with a history of severe anaphylactic reactions to allergens while taking beta-blockers

Therapeutic Class

  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep below 30°C temperature
  • Keep away from light and moisture
  • Keep out of the reach of children

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