Dompa-S 10 mg (Tablet)

Unit Price: ৳ 3.00 (100's pack: ৳ 300.00)

Medicine Details

Category Details
Generic Domperidone maleate
Company Seema pharmaceuticals ltd
Also available as
Dompa 10 mg tablet Dompa s 5 mg suspension

Title

  • Dompa-S 10 mg Tablet

Category

  • Digestive Health
  • Medication
  • Gastrointestinal
  • Pharmacology

Description

  • Dopamine antagonist medication for treating nausea and vomiting.
  • Gastroprokinetic action on the gastrointestinal tract.

DosageAndAdministration

  • Oral dose for adults: 10-20 mg every 6-8 hours daily, maximum 80 mg daily
  • Oral dose for children: 2-4 ml/10 kg body weight every 6-8 hours daily.

Indications

  • Dyspeptic symptom complex
  • Acute nausea and vomiting
  • Parkinson's disease induced nausea and vomiting
  • Radiological studies for speeding barium transit.

Pharmacology

  • Dopamine antagonist
  • Acts on Chemoreceptor Trigger Zone (CTZ) and stomach
  • Restores normal motility and tone of upper gastrointestinal tract.

Interaction

  • Antagonized by anticholinergic drugs
  • Lowered bioavailability with antacids and antisecretory drugs
  • Metabolic pathway through CYP3A4

Contraindications

  • Hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage, mechanical obstruction, or perforation
  • Prolactin releasing pituitary tumor

SideEffects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena in adults
  • Possible increase in plasma prolactin level

PregnancyLactation

  • Use only during first trimester if justified by therapeutic benefit
  • Excreted in breast milk at lower concentrations than plasma.

PrecautionsWarnings

  • Caution in use for children due to risk of extra-pyramidal reactions
  • Use with caution in hepatic impairment

UseInSpecialPopulations

  • Caution in infants due to incomplete blood-brain barrier
  • Caution in hepatic impairment
  • Caution in severe renal insufficiency

OverdoseEffects

  • Drowsiness, disorientation, and extrapyramidal reactions
  • Activated charcoal recommended in case of overdosage

TherapeuticClass

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

StorageConditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of children's reach

ChemicalStructure

  • Molecular Formula: C22H24ClN5O2
  • Chemical Structure: Image available at provided URL

CommonlyAskedQuestions

  • Use for treating nausea and vomiting
  • Quick tips on consumption and side effects.

ModeOfAction

  • Blocks dopamine receptors in CTZ and stomach
  • Gastroprokinetic action based on dopamine receptor blocking.

IndicationDetails

  • Dyspeptic symptoms include epigastric fullness, abdominal pain, flatulence, nausea, and heartburn
  • Acute nausea and vomiting due to various origins
  • Functional induced nausea and vomiting in Parkinson's disease
  • Speeding barium transit in radiological studies

AdditionalInformation

  • In vitro data suggests potential drug interactions through CYP3A4 pathway
  • Rare allergic reactions including rash and urticaria reported

DosingDetails

  • Different oral doses for dyspeptic symptoms and acute conditions
  • Rectal administration doses for adults and children
  • Max period of treatment is 12 weeks for acute nausea and vomiting.

SpecialPrecautions

  • Use with caution in patients with liver or kidney disorders
  • Avoid exceeding 7 day treatment period without consulting a doctor.

SafetyInformation

  • Domperidone does not affect mental alertness
  • Rare allergic reactions reported, including rash and urticaria.

InfantUse

  • Caution in use due to immature blood-brain barrier and potential neurological side effects
  • Increased dosing interval recommended in severe renal insufficiency.
  • Regular review advised for patients on prolonged therapy.

ProductUse

  • For relief from nausea, vomiting, and indigestion
  • Precautions and side effects related to alcohol consumption
  • Recommendations for managing dry mouth as a side effect.

ChemicalStructureDetails

  • Molecular formula and structural image provided for informed understanding.

QuickTips

  • Relieves nausea, vomiting, and indigestion
  • Take before meals as per doctor's prescription
  • Caution advised for activities requiring mental focus.
  • Avoid alcohol consumption during treatment period.

ToxicityInformation

  • Symptoms of overdosage include drowsiness, disorientation, and extrapyramidal reactions
  • Activated charcoal recommended in case of overdosage.

MolecularFormula

  • C22H24ClN5O2

DosageRestrictions

  • Max oral dose of 80 mg daily for adults
  • Max rectal dose for children based on body weight.
  • Max treatment period of 12 weeks for acute nausea and vomiting.

SideEffectsDetails

  • Rare extrapyramidal phenomena in adults and uncommon in young children
  • Hyperprolactinaemia potential leading to neuroendocrinological effects

DrugStorage

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of children's reach.

DomperidoneUse

  • Contraindicated in cases of hypersensitivity to the drug and in neonates
  • Should not be used in dangerous gastrointestinal stimulations.

PharmacologicalAction

  • Restores normal motility and tone of upper gastrointestinal tract
  • Facilitates gastric emptying and regulates pylorus contraction.

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