Tetraben 12.5 mg (Tablet)

Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Tetrabenazine
Company Incepta pharmaceuticals ltd
Also available as
Tetraben 25 mg tablet

Indications

  • Treatment of chorea associated with Huntington's disease

Pharmacology

  • Former antipsychotic
  • Symptomatic treatment of hyperkinetic disorders
  • Vesicular monoamine transporter-2 (VMAT-2) inhibitor

Dosage & Administration

  • Can be taken with or without food
  • Requires careful weekly titration
  • Start with 12.5 mg daily for the 1st week
  • Maximum daily dose not to exceed 50 mg (poor metabolizers) or 100 mg (extensive/intermediate metabolizers)

Interaction

  • Reduction in dose with strong CYP2D6 inhibitors
  • At least 20 days gap required after stopping reserpine before starting Tetraben
  • No interaction with food

Contraindications

  • Actively suicidal or untreated/undertreated depression
  • Hepatic impairment
  • Concurrent use of MAOIs, reserpine, deutetrabenazine, or valbenazine

Side Effects

  • Common adverse reactions: sedation/somnolence, fatigue, insomnia, depression, akathisia, anxiety, nausea
  • Rare adverse reactions: suicidal thoughts, neuroleptic malignant syndrome, pneumonia

Pregnancy & Lactation

  • No adequate data on developmental risk in pregnant women
  • No data on presence in human milk

Precautions & Warnings

  • Periodic re-evaluation of benefit and potential adverse effects
  • Maximum daily dose should not exceed 50 mg/day
  • Impairment of driving or operating machinery
  • Not recommended in combination with drugs that prolong QTc

Overdose Effects

  • Drowsiness, sweating, hypothermia

Therapeutic Class

  • Atypical neuroleptic drugs

Storage Conditions

  • Store in cool, dry place
  • Protect from light and moisture
  • Keep out of reach of children

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