Tetraben 12.5 mg (Tablet)
Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tetrabenazine |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of chorea associated with Huntington's disease
Pharmacology
- Former antipsychotic
- Symptomatic treatment of hyperkinetic disorders
- Vesicular monoamine transporter-2 (VMAT-2) inhibitor
Dosage & Administration
- Can be taken with or without food
- Requires careful weekly titration
- Start with 12.5 mg daily for the 1st week
- Maximum daily dose not to exceed 50 mg (poor metabolizers) or 100 mg (extensive/intermediate metabolizers)
Interaction
- Reduction in dose with strong CYP2D6 inhibitors
- At least 20 days gap required after stopping reserpine before starting Tetraben
- No interaction with food
Contraindications
- Actively suicidal or untreated/undertreated depression
- Hepatic impairment
- Concurrent use of MAOIs, reserpine, deutetrabenazine, or valbenazine
Side Effects
- Common adverse reactions: sedation/somnolence, fatigue, insomnia, depression, akathisia, anxiety, nausea
- Rare adverse reactions: suicidal thoughts, neuroleptic malignant syndrome, pneumonia
Pregnancy & Lactation
- No adequate data on developmental risk in pregnant women
- No data on presence in human milk
Precautions & Warnings
- Periodic re-evaluation of benefit and potential adverse effects
- Maximum daily dose should not exceed 50 mg/day
- Impairment of driving or operating machinery
- Not recommended in combination with drugs that prolong QTc
Overdose Effects
- Drowsiness, sweating, hypothermia
Therapeutic Class
- Atypical neuroleptic drugs
Storage Conditions
- Store in cool, dry place
- Protect from light and moisture
- Keep out of reach of children