Tetraben 25 mg (Tablet)
Unit Price: ৳ 35.00 (2 x 10: ৳ 700.00)
Strip Price: ৳ 350.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tetrabenazine |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of chorea associated with Huntington's disease
Pharmacology
- Vesicular monoamine transporter-2 (VMAT-2) inhibitor
Dosage & Administration
- Can be taken with or without food
- Individualization of dose with careful weekly titration required
- First week's starting dose: 12.5 mg daily
- Maximum recommended single dose not to exceed 25 mg
- Genotyping recommended for patients requiring doses above 50 mg per day
- Pediatric & geriatric use: Safety and effectiveness not established
Interaction
- Reduction in dose when adding strong CYP2D6 inhibitors
- 20 days gap required after stopping reserpine before starting Tetraben
- No interaction with food
Contraindications
- Actively suicidal or untreated/undertreated depression
- Hepatic impairment
- Concurrent use of monoamine oxidase inhibitors (MAOIs) or reserpine
- Concurrent use of deutetrabenazine or valbenazine
Side Effects
- Common: Sedation/somnolence, fatigue, insomnia, depression, akathisia, anxiety, nausea
- Rare: Suicidal thoughts, neuroleptic malignant syndrome, pneumonia
Pregnancy & Lactation
- No adequate data on developmental risk in pregnant women
- No data on presence in human milk
Precautions & Warnings
- Periodic re-evaluation of benefit and potential adverse effects
- Maximum daily dose of 50 mg/day and maximum single dose of 25 mg with strong CYP2D6 inhibitor
- Discontinue treatment in case of Neuroleptic Malignant Syndrome
- Impairment of ability to drive or operate machinery
- Not recommended in combination with other drugs that prolong QTc
Overdose Effects
- Signs and symptoms may include drowsiness, sweating, hypothermia
Therapeutic Class
- Atypical neuroleptic drugs
Storage Conditions
- Store in cool & dry place
- Protect from light & moisture
- Keep out of the reach of children