Tetraben 25 mg (Tablet)

Unit Price: ৳ 35.00 (2 x 10: ৳ 700.00)

Strip Price: ৳ 350.00

Medicine Details

Category	Details
Generic	Tetrabenazine
Company	Incepta pharmaceuticals ltd
Also available as	Tetraben 125 mg tablet

Indications

Treatment of chorea associated with Huntington's disease

Pharmacology

Vesicular monoamine transporter-2 (VMAT-2) inhibitor

Dosage & Administration

Can be taken with or without food
Individualization of dose with careful weekly titration required
First week's starting dose: 12.5 mg daily
Maximum recommended single dose not to exceed 25 mg
Genotyping recommended for patients requiring doses above 50 mg per day
Pediatric & geriatric use: Safety and effectiveness not established

Interaction

Reduction in dose when adding strong CYP2D6 inhibitors
20 days gap required after stopping reserpine before starting Tetraben
No interaction with food

Contraindications

Actively suicidal or untreated/undertreated depression
Hepatic impairment
Concurrent use of monoamine oxidase inhibitors (MAOIs) or reserpine
Concurrent use of deutetrabenazine or valbenazine

Side Effects

Common: Sedation/somnolence, fatigue, insomnia, depression, akathisia, anxiety, nausea
Rare: Suicidal thoughts, neuroleptic malignant syndrome, pneumonia

Pregnancy & Lactation

No adequate data on developmental risk in pregnant women
No data on presence in human milk

Precautions & Warnings

Periodic re-evaluation of benefit and potential adverse effects
Maximum daily dose of 50 mg/day and maximum single dose of 25 mg with strong CYP2D6 inhibitor
Discontinue treatment in case of Neuroleptic Malignant Syndrome
Impairment of ability to drive or operate machinery
Not recommended in combination with other drugs that prolong QTc

Overdose Effects

Signs and symptoms may include drowsiness, sweating, hypothermia

Therapeutic Class

Atypical neuroleptic drugs

Storage Conditions

Store in cool & dry place
Protect from light & moisture
Keep out of the reach of children

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