Traxef 2 gm/vial (IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. It has a long plasma elimination half-life of about 6 to 9 hours. Ceftriaxone is not metabolized in the body and is highly protein bound (95%).
Dosage
- Adult: 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Infants and Children (01 month or older): 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.
Administration
- Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
- Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection
- The injection should be administered over 2-4 minutes by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes at concentration between 10 mg/mL and 40 mg/mL.
Interaction
No drug interactions have been reported.
Contraindications
Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.
Side Effects
- Gastrointestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
- Cutaneous reactions including rash, pruritus, urticaria
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
- Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
- Local phlebitis occurs rarely following intravenous administration
Pregnancy & Lactation
Its safety in human pregnancy has not been established. Caution should be exercised when Ceftriaxone is administered to a lactating mother.
Precautions & Warnings
- Anaphylactic shock cannot be ruled out even if a thorough patient history is taken
- Anaphylactic shock requires immediate countermeasures such as intravenous epinephrine followed by a glucocorticoid
- Shadows suggesting sludge have been detected by sonograms of the gallbladder
Use in Special Populations
Traxef must not be given to neonates if they are premature and newborn (up to 28 days of age)
Overdose Effects
There is no specific antidote. Treatment of overdosage should be symptomatic.
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Vial store in a cool, dry place (below 30°C), away from light & moisture.