Levetam XR 500 mg (Tablet (Extended Release))
Unit Price: ৳ 30.00 (2 x 10: ৳ 600.00)
Strip Price: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Levetiracetam |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of partial-onset seizures with or without secondary generalization in adults and adolescents
- Adjunctive therapy for various types of seizures in adults, adolescents, children, and infants
Description
- Precise mechanism of antiepileptic effect is unknown
- Minimal activity in submaximal stimulation and threshold tests
- Inhibition of burst firing without affecting normal neuronal excitability
- Selective prevention of hyper synchronization of epileptiform burst firing
Dosage
- Recommended starting dose for adults and adolescents
- Increase of dose based on clinical response
- Different dose recommendations for pediatric population
- Use of oral solution for infants and children under 6 years
Administration
- Oral administration
- Swallowed with sufficient quantity of liquid
- Divided doses
Interaction
- No influence on serum concentrations of existing antiepileptic medicinal products
- Inhibition of renal clearance of a primary metabolite
- Decrease in methotrexate clearance
- Reports of decreased efficacy when concomitantly administered with osmotic laxative
Contraindications
- Hypersensitivity to active substance or other pyrrolidone derivatives
Side Effects
- Most common adverse reactions in adult and pediatric patients
Pregnancy & Lactation
- Not recommended during pregnancy or breastfeeding
- Excretion in human breast milk
- No impact on fertility in animal studies
Precautions & Warnings
- Dose adjustment for renal impairment
- Rare cases of decreased blood cell counts
- Association with acute kidney injury
- Monitoring for signs of depression, suicidal ideation, and behavior
- Appropriate treatment for depression and suicidal ideation and behaviors
- Use in special populations such as elderly, renal impaired, and hepatic impaired individuals
Use in Special Populations
- Adjustment of dose in elderly patients with compromised renal function
- Individualized dose according to renal function
- No dose adjustment in patients with mild to moderate hepatic impairment
Overdose Effects
- Observations of somnolence, agitation, aggression, and respiratory depression
- No specific antidote
- Symptomatic treatment and potential haemodialysis
Therapeutic Class
- Adjunct anti-epileptic drugs
Storage Conditions
- Store at a cool temperature not exceeding 25°C
- Protect from light