Linera M 2.5 mg+1000 mg (Tablet)
Unit Price: ৳ 16.00 (4 x 8: ৳ 512.00)
Strip Price: ৳ 128.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise
- Improves glycemic control
- Type 2 diabetes mellitus
Pharmacology
- Inhibitor of DPP-4 enzyme
- Increases concentration of active incretin hormones
- Stimulates insulin release from pancreatic beta cells
- Decreases glucagon secretion from pancreatic alpha cells
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Improves insulin sensitivity
- Decreases hepatic glucose production
Dosage & Administration
- Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
- Gradual dose escalation recommended
- Individualized dosage based on effectiveness and tolerability
Interaction
- Potential interaction with cationic drugs
- Concomitant use of carbonic anhydrase inhibitors may induce metabolic acidosis
- Rifampin decreases Linagliptin exposure
- Drugs affecting glycemic control may lead to loss of control
Contraindications
- Contraindicated in patients with renal impairment
- Contraindicated in acute or chronic metabolic acidosis
- Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Most common side effects: nasopharyngitis and diarrhea
- Hypoglycemia more common in patients treated with Linera M and sulfonylureas
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Caution advised during lactation
Precautions & Warnings
- Immediate discontinuation in case of lactic acidosis
- Postmarketing reports of acute pancreatitis
- Hematologic parameters monitoring annually due to potential lowering of Vitamin B12 levels
Overdose Effects
- Usual supportive measures in event of overdose
- Hypoglycemia reported in approximately 10% of cases
- Lactic acidosis reported in approximately 32% of cases
Therapeutic Class
- Combination oral hypoglycemic preparations
Storage Conditions
- Store below 30°C
- Protect from light and moisture
- Keep out of reach of children